1 What is Florinef?

Brand: Florinef

Generic: Fludrocortisone Acetate

Florinef Acetate is a drug used in the treatment of primary and secondary adrenocortical insufficiency in Addison's disease. It is also used to treat salt-losing adrenogenital syndrome. This drug is available as a tablet containing fludrocortisone acetate 0.1 milligram.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Florinef may interact with medications such as:

  • Aldesleukin
  • Aspirin or nonsteroidal anti-inflammatory drugs such as:
    • Ibuprofen
    • or Indomethacin
  • Blood thinners such as:
    • Warfarin
  • Digoxin
  • Hormones such as:
  • Immunosuppressants
  • Mifepristone
  • Vaccines
  • Drugs that may cause potassium loss such as:
    • Amphotericin B
    • or Diuretics such as:
      • Furosemide
      • or Thiazides
  • Drugs affecting liver enzymes that remove fludrocortisone from the body such as:
    • Rifamycins
    • or Certain anti-seizure medicines such as:
      • Barbituates
      • or Phenytoin

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to fludrocortisone
  • Fungal infection in your blood such as:
  • Bleeding problems
  • Blood clots
  • Osteoporosis
  • Diabetes
  • Eye problems
  • Heart problems
  • High blood pressure
  • Infections
  • Kidney disease
  • Liver disease
  • Psychiatric disorders
  • Electrolyte imbalance
  • Gastrointestinal problems
  • Seizures
  • Thyroid problems
  • Pregnancy or lactation