Fragmin

1 What is Fragmin?

Brand: Fragmin

Generic: Dalteparin

Fragmin, a low molecular weight heparin, is indicated for the treatment and prevention of blood clots. Conditions that may necessitate dalteparin include deep venous thrombosis.

Clots can also travel and eventually get lodged in the lungs’ blood vessels which can then lead to a pulmonary embolism.

Dalteparin is used to prevent blood clot formation in patients with unstable coronary artery disease.

This medication can also be given to patients who have recently undergone abdominal and hip replacement surgery. Cancer patients may be given this medicine for extended blood clot treatment.

Dalteparin can only be purchased with a doctor’s prescription. It is sold as an injectable or a solution.

2 What to Know Before Using

Before using Fragmin, you and your treating physician need to talk about the pros and cons. There are several factors to consider.

This medication should not be given to patients who have had allergic reactions to dalteparin. You should also tell your doctor if you are allergic to any food, animal, preservative, and other drugs.

The safety and efficacy of subcutaneous dalteparin in pediatric patients have not been studied extensively. However, research has shown that dalteparin works as indicated in the geriatric population.

Necessary dose adjustments must be made to ensure safety and efficacy. Dalteparin has a pregnancy category of B meaning that there have been inadequate studies on pregnant women.

It is also not known if dalteparin can put the infant at risk. If you are pregnant or breastfeeding, you should tell your physician so that he/she can explain the risks and benefits.

Concomitant use of the following is normally not recommended but can be necessary:

  • abciximab
  • aceclofenac
  • alipogene tiparvovec
  • amtolmetinguacil
  • apixaban
  • celecoxib
  • choline salicylate
  • dabigatran etexilate
  • dexketoprofen
  • dipyridamole
  • edoxaban
  • etodolac
  • fenofibrate
  • fluvoxamine
  • ibuprofen lysine
  • ketorolac
  • meclofenamate
  • naproxen
  • oxaprozin
  • phenindione
  • proquazone
  • sertraline
  • sulfinpyrazone
  • tenoxicam
  • tinzaparin
  • treprostinil
  • valdecoxib
  • vilazodone
  • vortioxetine
  • warfarin

Your doctor may adjust the timing and dosage of either or both drugs. Using palifermin while taking dalteparin can put you at risk of developing side effects.

Certain medical conditions can also influence the safety and efficacy of dalteparin. This medicine should not be given to patients with pork allergy, active bleeding, thrombocytopenia, or receiving regional anesthesia.

Dalteparin should be used with caution in individuals with the following conditions because the risk of bleeding is high:

  • the presence of a spinal catheter
  • bleeding problems
  • eye problems related to diabetes or high blood pressure
  • heart infection
  • severe hypertension
  • kidney disease
  • liver disease
  • active ulcers or bleeding in the stomach or intestines
  • stroke
  • thrombocytopenia
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3 Proper Usage

To use Fragmin correctly, you must follow all instructions given by your doctor.

Dalteparin should be administered by a trained medical professional while you are in the hospital. It is injected into fatty areas of your body like the buttocks, thighs, or abdomen.

If you are taking dalteparin at home, your physician will demonstrate the proper way to inject yourself as well as where to inject. Use a different site for every injection and keep track of the areas you recently used.

Throw away medications that have changed in color. Make sure you discard old syringes and needles in a puncture-proof container. The dosage of dalteparin will depend on your condition.

To prevent deep venous thrombosis, adult patients should receive 5,000 international units subcutaneously daily for 12 to 14 days.

To prevent blood clots from forming post unstable angina or non–Q-wave myocardial infarction, adult patients should get 120 international units/kg of body weight every 12 hours in 5 to 8 days.

In hip replacement surgery, adults need 5,000 international units pre-op and 5,000 international units 4 to 8 hours post-op. If you are taking dalteparin at home and you missed a dose, administer it as soon as you remember.

Skip it though if it’s almost time for the next one. You need to store this medicine at room temperature and away from the reach of children. Throw away used syringes as instructed by your healthcare provider.

4 Precautions to Take

Before using Fragmin, there are some precautions you must take.

Go to your follow-up appointments diligently and follow your doctor’s instructions regarding the proper use of dalteparin.

Let your dentist and/or other doctors know that you are taking this medicine before having anything done. Dalteparin can increase bleeding risk.

You should consult your physician if you have unusual bleeding/bruising, black/tarry stools, hematuria, or pinpoint red spots. You should also watch out for symptoms of thromboembolism.

These can include pain in the chest, groin, legs, or calves; slurred speech, severe headaches, unexplained shortness of breath, a sudden weakness of the upper and lower limbs, and loss of coordination.

Fragmin multi-dose vials should not be used in pregnant women because it contains benzyl alcohol, which is harmful to the fetus.

Check with your doctor before you take other medications whether prescription or OTC drugs.

5 Potential Side Effects

There are several side effects associated with Fragmin use, but you may not experience all of them.

You need to check with your doctor right away if you have:

  • pain
  • a dark purple bruise
  • swelling at the injection site
  • gum bleeding
  • the difficulty with breathing or swallowing
  • increased menstrual flow or vaginal bleeding
  • nosebleeds
  • paralysis
  • coffee-ground vomitus
  • weakness

Other effects include back pain, mucosal bleeding, redness of the skin, fever, problems with bowel or bladder function, sloughing of the skin at the injection site, and swelling of the eyelids, face, or lips.

If you experience other unusual effects, get in touch with your doctor right away.

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