1 What is Gen-Xene?

Brand: Gen-Xene, Tranxene, Tranxene-SD, Tranxene T-Tab

Generic: Clorazepate

Gen-Xene is a benzodiazepine used to treat partial seizures and relieve symptoms of anxiety and alcohol withdrawal. 

This drug activates your neurotransmitter inhibitors that slow down the nervous system. This drug requires a prescription.

2 What to Know Before Using

Before using Gen-Xene, the risks and benefits for your body should be discussed with your healthcare provider. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. 

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies of this drug in children below 9 years of age have not been performed. Also, studies in the elderly have not demonstrated any geriatric-specific problems that would limit the usefulness of clorazepate. 

Adjustments in the dose of the elderly may be required as they are more likely to have confusion and severe drowsiness, or age-related heart, liver, or kidney problems. Teratogenic effects have not been demonstrated in studies of pregnant women. Studies regarding infant risk when taking this drug during breastfeeding are still inadequate. 

Discuss with your healthcare professional the possible risks and benefits before taking this drug while breastfeeding. Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects. 

Inform your healthcare professional if you are taking any other drugs such as: 

  • Alfentanil Amobarbital
  • Anileridine
  • Bromazepam
  • Buprenorphine
  • Butabarbital
  • Butalbital
  • Carbamazepine
  • Carbinoxamine
  • Carisoprodol
  • Ceritinib
  • Chloral Hydrate
  • Chlorzoxazone
  • Clarithromycin
  • Codeine
  • Dantrolene
  • Ethchlorvynol
  • Fentanyl
  • Flibanserin
  • Fospropofol
  • Hydrocodone
  • Hydromorphone
  • Idelalisib
  • Ketoconazole
  • Levorphanol
  • Meclizine
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methocarbamol
  • Methohexital
  • Morphine
  • Morphine Sulfate Liposome
  • Nilotinib
  • Orlistat
  • Oxycodone
  • Oxymorphone
  • Pentobarbital
  • Phenobarbital
  • Primidone
  • Propofol
  • Propoxyphene
  • Remifentanil
  • Secobarbital
  • Sodium Oxybate
  • Sufentanil
  • Suvorexant
  • Tapentadol
  • Thiopental
  • Zolpidem
  • Amiodarone
  • Desipramine
  • Ginkgo
  • Nevirapine,
  • Ritonavir
  • St John's Wort
  • Theophylline. 

Intake of specific food or using alcohol or tobacco with magnesium is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. 

Inform your healthcare provider for any other medical problems such as depression, lung or breathing problems, glaucoma, liver or kidney disease.

3 Precautions to Take

Before using Gen-Xene, there are some precautions you must take.

Your healthcare provider should closely monitor the effectiveness of this drug as well as check for unwanted effects. Unwanted effects may be screened using blood tests. This drug is teratogenic and undergoing a pregnancy test is recommended as this drug can harm your unborn baby when taken during pregnancy. 

Use of effective forms of birth control is recommended to prevent pregnancy. Inform your healthcare professional immediately if you experience symptoms of pregnancy. This drug may cause drowsiness, trouble with thinking, trouble with controlling movements, or trouble with seeing clearly. 

Be careful in taking this medicine before you drive, use machines, or do anything else that could be dangerous. This drug may cause agitation, irritability, other abnormal behaviors, suicidal thoughts and tendencies or to become more depressed. 

Inform you. Consult with your healthcare professional before you taking this drug. Your healthcare professional may slowly taper the amount you are taking before stopping it completely to prevent your condition from worsening and reduce the possibility of withdrawal symptoms, such as convulsions, hallucinations, stomach or muscle cramps, tremors, or unusual behavior. 

This potentiates the effects of alcohol and other central nervous system (CNS) such as drugs for allergies or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Consult with your healthcare provider before taking any of these drugs.

4 Potential Side Effects

As with many medications, there are several potential side effects associated with Gen-Xene. Side effects may vary for each individual and prompt medical attention should be given if they occur. 

Inform you healthcare provider immediately if you experience any unusual symptoms such as: 

  • difficulty with swallowing
  • fever
  • shakiness and unsteady walk
  • unsteadiness
  • trembling or other problems with muscle control or coordination
  • change in speech pattern
  • restlessness
  • slurred speech
  • trouble sitting still
  • trouble speaking
  • agitation
  • black, tarry stools
  • bleeding gums
  • blistering
  • peeling or loosening of the skin
  • blood in the urine or stools
  • chest pain
  • chills
  • confusion as to time, place, or person
  • cough
  • diarrhea
  • difficult or troubled breathing
  • holding false beliefs that cannot be changed by fact,
  • rregular, fast or slow, or shallow breathing
  • itching
  • joint or muscle pain
  • lack of feeling or emotion
  • painful or difficult urination
  • pale or blue lips, fingernails, or skin
  • pinpoint red spots on the skin
  • red skin lesions often with a purple center red,
  • irritated eyes
  • seeing, hearing, or feeling things that are not there 
  • sore throat sores
  • ulcers
  • white spots in the mouth or on the lips 
  • swollen glands
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual excitement
  • nervousness or restlessness
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Ask your healthcare professional about ways to prevent or reduce some of these side effects. 

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. 

If any of the following side effects persists, or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

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