1 What is Hycomine?

Brand: Hycomine

Generic: Hydrocodone Bitartrate and Phenylpropanolamine Hydrochloride

Hycomine is a drug which is used for the relief of cough. This drug is available as a syrup containing hydrocodone bitartrate 5 milligrams in 5 milliliters and phenylpropanolamine hydrochloride 25 milligrams in 5 milliliters or hydrocodone bitartrate 2.5 milligrams in 5 milliliters and phenylpropanolamine hydrochloride 12.5 milligrams in 5 milliliters.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Hycomine may interact with medications such as:

  • Other anticholinergic drugs such as:
    • Belladonna alkaloids orbenztropine
  • Cimetidine
  • Narcotic antagonists such as:
    • Naltrexone
    • or Naloxone
  • Narcotic agonists or antagonists such as:
    • Butorphanol
    • or Nalbuphine
  • Potassium tablets or capsules
  • Pramlintide
  • MAO inhibitors:
  • Certain antihistamines such as:
    • Diphenhydramine
  • Anti-seizure drugs such as:
    • Carbamazepine
  • Medicine for sleep or anxiety such as:
    • Alprazolam
    • Diazepam
    • or Zolpidem
  • Muscle relaxants
  • Narcotic pain relievers such as:
    • Codeine
    • or Morphine
  • Psychiatric medicines such as:

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following: