1 What is Inspra?

Brand: Inspra

Generic: Eplerenone

Inspra is a drug used in the treatment of congestive heart failure after myocardial infarction (heart attack) and hypertension. It may be used with other anti-hypertensive agents.

This drug is available as a film coated tablet containing 25 mg or 50 mg of eplerenone.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Eplerenone may interact with medications such as:

  • ACE inhibitors such as captopril or enalapril
  • Angiotensin II blockers such as losartan or valsartan
  • Lithium
  • Potassium supplements
  • Potassium-sparing types such as amiloride, spironolactone or triamterene
  • Azole antifungals such as fluconazole, ketoconazole or itraconazole
  • Macrolide antibiotics (such as clarithromycin, erythromycin)
  • Nefazodone
  • Protease inhibitors such as nelfinavir, ritonavir or saquinavir
  • St. John's wort
  • Verapamil

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to eplerenone
  • High potassium blood levels or hyperkalemia
  • Severe kidney disease
  • Diabetes
  • Pregnancy or lactation

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