Kengreal

1 What is Kengreal?

Brand: Kengreal

Generic: Cangrelor

Kengreal injection is used in patients undergoing percutaneous coronary intervention (PCI) to lower the risk of blood clots and heart attack.

A heart attack or stroke may occur when a blood vessel in the heart or brain is blocked by a blood clot. 

Cangrelor reduces the chance that a harmful blood clot will form by preventing certain cells in the blood from clumping together. This effect of cangrelor may also increase the chance of serious bleeding in some people.

This medicine is to be given only by or under the supervision of your doctor.

This product is available in the following dosage forms:

  • Powder for Solution

2 What to Know Before Using

Before using Kengreal, you must know all about the risks and complications associated with it.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

1. Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

2. Pediatric Population:

Appropriate studies have not been performed on the relationship of age to the effects of cangrelor injection in the pediatric population. Safety and efficacy have not been established.

3. Geriatric Population:

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cangrelor injection in the elderly.

4. Pregnancy

Category C: Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

5. Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

6. Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

7. Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

8. Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding, active—Should not be used in patients with these conditions.

3 Proper Usage

To use Kengreal properly, you must follow all instructions given by your doctor.

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins. It is given before the start of PCI.

4 Precautions to Take

Before using Kengreal, there are some precautions you must take.

It is very important that your doctor check you closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects.

This medicine may increase your chance of bleeding and bruising. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Kengreal.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  • Abdominal or stomach pain or swelling
  • back pain
  • black, tarry stools
  • blood in the eyes
  • blood in the urine
  • bruising or purple areas on the skin
  • coughing up blood
  • decreased alertness
  • dizziness
  • headache
  • joint pain or swelling
  • nosebleeds

Less common

  • Difficult or labored breathing
  • tightness in the chest

Rare

  • Cough
  • difficulty with swallowing
  • fast heartbeat
  • hives, itching, or rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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