1 Dichlorphenamide (Oral Route): A Summary

Brand: Keveyis

Generic: Dichlorphenamide (Oral Route)

Keveyis is a carbonic anhydrase inhibitor used for the treatment of inherited muscle disorders, such as primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and related variants.

This drug requires a prescription.

2 What to Know Before Using

Before using Keveyis, you must know all about the risks and complications associated with it.

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children regarding the relationship of age to the effects of dichlorphenamide have not been performed while safety and efficacy have not been established.

Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of dichlorphenamide.

Adjustments in the dose of the elderly may be required since they are more likely to have falls or metabolic acidosis.

Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. Infant risk is still undetermined when using this drug during breastfeeding.

Discuss with your healthcare professional about the potential risks and benefits of taking this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as Aspirin, or Metformin.

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as Adrenal problems, Hyperchloremic metabolic acidosis, Respiratory acidosis, allergy to sulfa drugs, Liver disease, or Lung disease.

3 Proper Usage

To use Keveyis properly, you must follow all instructions given by your doctor.

To prevent any side effects, take this drug exactly as directed on the label or as prescribed by your healthcare professional. The dose of this drug will be variable for different patients.

The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

Adults with primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and related variants are initially given 50 milligrams two times a day.

Your healthcare professional may increase your dose if necessary. The dose must not exceed 200 mg per day. Use and dose in children must be determined by your healthcare professional.

A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

Before using Keveyis, there are some precautions you must take.

Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug. Unwanted effects can be screened using blood tests.

Inform your healthcare professional immediately if you have symptoms of anaphylaxis such as:

  • blistering
  • peeling or red skin rash
  • fever with or without chills
  • itching skin
  • lower back or side pain
  • painful or difficult urination
  • sore throat
  • sores, ulcers or white spots on the lips or in the mouth
  • unusual bleeding or bruising
  • yellow eyes or skin

Check with your healthcare professional if you have symptoms of hypokalemia such as:

  • convulsions
  • dry mouth
  • increased thirst
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet or lips
  • uneven heartbeat

This drug can cause drowsiness or tiredness which requires caution when taking this drug before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Check with your healthcare professional before you take any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Keveyis.

Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms.

Some side effects may occur that usually do not need medical attention. As your body adjusts to the drug, the side effects will slowly disappear.

Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

Report any side effects to the FDA hotline at 1-800-FDA-1088.

6 Related Clinical Trials