1 What is Lodine?

Brand: Lodine, Lodine XL

Generic: Etodolac

LodineĀ is a drug used in the treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis and other conditions with pain. This drug is available as a tablet containing 400 mg or 500 mg of etodolac. This is also available as an extended release tablet containing 400 mg, 500 mg or 600 mg of etodolac.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Etodolac may interact with medications such as:

  • Aliskiren
  • ACE inhibitors such as captopril or lisinopril
  • Angiotensin II receptor blockers such as losartan or valsartan
  • Cidofovir
  • Clopidogrel
  • Blood thinners such as enoxaparin or warfarin
  • Bisphosphonates such as alendronate
  • Corticosteroids such as prednisone
  • SSRI antidepressants such as fluoxetine or sertraline
  • Aspirin and NSAIDs such as celecoxib, ibuprofen, or ketorolac

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

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