1 What is Lynparza?

Brand: Lynparza

Generic: Olaparib

Lynparza is used to treat advanced ovarian cancer. It is an antineoplastic drug. It works by killing cancer cells.

It is used in patients who have already received multiple cancer drugs before. It is only effective against those cancers which have BRCA mutations.

It may also be used for other conditions prescribed by your doctor. It is only available in the form of a capsule and only with your doctor’s prescription.

2 What to Know Before Using

Your doctor will inform you of what you need to know before using Lynparza.

Before starting the treatment your doctor should be informed about conditions such as:

Allergy: Inform your doctor if you are allergic to any food, preservatives, dyes, or had an allergic reaction when you used this drug before.

Children: There are no adequate studies done which prove Olaparib harmful effects in children. Use it after consulting your doctor.

Elderly: This medicine does not cause any different side effects or problem than it does in younger adults.

Pregnancy: It is a category D drug. It is not safe to use in pregnancy. It may cause harm to an unborn baby and can result in the loss of an unborn baby.

Breast Feeding: Olaparib is not known if it can pass into breast milk or not. Do not use this medication while nursing your child.

Drug Interactions: Olaparib may interact with other drugs. Your doctor should be informed of any other medicines which you are taking. He may want to change the dosage or drug.

Some of them are listed below:

  • • Amprenavir
  • Aprepitant
  • Atazanavir
  • Boceprevir
  • Ciprofloxacin
  • Clarithromycin
  • Crizotinib
  • Darunavir/Ritonavir
  • Diltiazem
  • Erythromycin
  • Fluconazole
  • Fosamprenavir
  • Imatinib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Lopinavir/Ritonavir
  • Nefazodone
  • Nelfinavir
  • Posaconazole
  • Ritonavir
  • Saquinavir
  • Telaprevir
  • Telithromycin
  • Verapamil
  • Voriconazole, because they may increase the risk of Olaparib's side effects
  • Bosentan
  • Carbamazepine
  • Efavirenz
  • Etravirine
  • Modafinil
  • Nafcillin
  • Phenytoin
  • Rifampin
  • St. John's wort because they may decrease Olaparib's effectiveness

This is not a complete list of drugs. Grapefruit juice may also reduce its effectiveness.

Several other conditions may reduce its effectiveness.

Make sure you inform your doctor of conditions such as:

  • Myelodysplastic syndrome (bone marrow disease)
  • Acute myeloid leukemia
  • Lung disease

3 Proper Usage

To use Lynparza properly, you must follow all instructions given by your doctor.

Use it exactly as your doctor directed. Read the medication guide carefully. Ask your pharmacist if you have any queries.

Swallow the medicine whole. Do not crush, chew or break it. Do not take it if it is deformed or leaking. Continue to take Olaparib even if you feel well. Do not miss any doses.

Avoid food or drink containing grapefruit or Seville oranges while you are taking Olaparib.

Dosage: It is different for different patients. Dosage mentioned below is an average dose. You must follow your doctor’s command.

For advanced ovarian cancers: 400 milligrams (mg) two times a day. For children, the dose is determined by doctors.

Missed dose: If you miss a dose, take it as soon as you remember it. If it almost a time for your next dose skips the missed dose and continue your daily schedule. Doubling the dose is harmful

Storage: Store it at room temperature. Keep it away from children.

4 Precautions to Take

Before using Lynparza, there are some precautions you must take.

Your doctor should check your daily progress at regular visits. He may do a blood and urine test.

Olaparib is known to cause bone marrow diseases. Inform your doctor if you experience fever, blood in the urine or stool, chills, unusual bleeding, bruising, tiredness, or weakness, or weight loss.

These are signs of myelodysplastic syndrome and acute myeloid Leukemia (bone marrow diseases).

Olaparib may cause serious lung diseases. Inform your doctor if you experience any chest pain or difficulty in breathing.

While using Olaparib, use a very effective form of birth control pill during and after 1 month of treatment.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Lynparza. Some people may experience none or minor side effects.

Consult with your doctor if they become problematic or frequent:

Most common are:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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