1 What is Makena?

Brand: Makena

Generic: Hydroxyprogesterone Caproate

Makena is a drug used to reduce the risk of preterm birth in women at risk for such. This drug is available as an injectable sterile solution containing 1250 mg / 5 ml of hydroxyprogesterone caproate.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be injected intramuscularly usually weekly by a health care professional. Your dosage is based on your medical condition and the way you will respond to treatment.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Tell your doctor about prescription or nonprescription drugs and herbal products you may use with Hydroxyprogesterone caproate.

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to hydroxyprogesterone
  • Asthma
  • Blood clots or other blood clotting problems
  • Cancer (especially of the breast or other female organs)
  • Depression
  • Diabetes
  • Severe headaches or migraines
  • Heart problems
  • High blood pressure
  • Kidney problems
  • Liver problems
  • Seizure disorder
  • Unusual vaginal bleeding
  • Yellowing eyes or skin (jaundice) during pregnancy
  • Pregnancy or breastfeeding