Marqibo is an antineoplastic drug (cancer drug). It is used in the treatment of certain types of leukemia especially Philadelphia chromosome negative acute lymphoblastic leukemia (Ph-ALL).
It works by killing certain cancer cells. It is used in patients who have already received multiple cancer drugs before.
It is available in the form of solution and suspension and is only given by or under your doctor’s supervision.
2 What to Know Before Using
Before using Marqibo, you must know all about the risks and complications associated with it.
Tell your doctor if you have any allergies to food, preservatives, dyes and animals or had an allergic reaction which occurred while using this drug before.
It should be used with extreme caution as safety and efficacy have not been established.
This medicine does not cause any different side effects or problem than it does in younger adults. However, safety and efficacy have not been established.
It is a category D drug. It is not safe to use during pregnancy as it may cause harm to an unborn baby. Do not become pregnant while using vincristine.
Vincristine liposomal injection is not known if it passes into breast milk. It is better not to breastfeed while using it. If you are or will be breast-feeding while you use Vincristine liposomal injection, check with your doctor. Discuss any possible risks to your baby.
Vincristine liposomal injection interacts with many drugs. It should not be used with several drugs. Your doctor should be informed of any other medicine which you are taking as he/she may change the drug or its dosage.
Some of them are listed below,
Following drugs may increase the risk of vincristine liposomal injection's side effects
Following drugs may decrease vincristine liposomal injection's effectiveness
St. John's wort
Other Medical Conditions
Several other conditions may reduce its effectiveness. Make sure you inform your doctor of conditions such as:
If you have a current or recent infection (eg, herpes zoster infection or shingles, chickenpox)
bone marrow problems (low blood platelets, low white blood cells)
Charcot Marie tooth syndrome (a genetic nerve disorder): should not be used in patients with this condition.
3 Proper Usage
Proper usage of Marqibo requires strict adherence to your doctor’s orders. Read the medication guide carefully. Ask your pharmacist if you have any queries. It is important for you to work closely with your doctor during your treatment.
Vincristine liposome is given as an injection into your vein by a doctor or healthcare professional in a hospital. It is recommended that you should drink plenty of fluids when you are having this treatment.
4 Precautions to Take
Before using Marqibo, there are some precautions you must take. Your doctor should check your daily progress at regular visits. He may do a blood and urine test.
While using vincristine, use a very effective form of birth control pill, as it may cause harm or loss to an unborn baby.
A serious and possibly fatal condition called tumor lysis syndrome (TLS) has been reported in patients taking vincristine liposomal injection.
Inform your doctor immediately if you notice any change in frequency of:
rapid weight gain
pain in joints and muscles
feeling tired and swelling of feet and lower leg
Do not drive or perform other possibly unsafe tasks until you know how you react to it as it may cause tingling, numbness or tiredness.
5 Potential Side Effects
As with many medications, there are several potential side effects associated with Marqibo. Some people may experience none or minor side effects. Consult with your doctor if they become problematic or frequent.
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