Mavik

1 What is Mavik?

Brand: Mavik

Generic: Trandolapril

Mavik is used to treat hypertension (high blood pressure) and heart failure. It is an ACE (angiotensin-converting enzyme) inhibitor.

By inhibiting ACE it causes relaxation of vessels and also decreases absorption of water by the kidney, both help in reducing pressure on vessels and thus increasing the supply of blood and oxygen to the heart.

Trandolapril is also used to increase survival rate after heart attack. It is available in the capsule and tablet form only with your doctor’s prescription.

2 What to Know Before Using

Your doctor will inform you of what you need to know before using Mavik.

Allergy

Inform your doctor if you are allergic to any food, preservatives, dyes, or had an allergic reaction when you used this drug before.

Children

There are no adequate studies done which prove Trandolapril’s harmful effects in children. Use it after consulting your doctor. However, safety and efficacy have not been established.

Elderly

This medicine does not cause any different side effects or problem than it does in younger adults. However, it should be used with caution if there are kidney problems.

Pregnancy

It is a category D drug. It should not be used in pregnancy. It can cause harm and can cause the death of an unborn baby.

Breast Feeding

Trandolapril passes into breast milk. Do not breast-feed while using it as may cause harmful effects in the baby.

Drug Interactions

Trandolapril may interact with other drugs. Your doctor should be informed of any other medicines which you are taking. He/she may want to change the dosage or drug.

Some of them are listed below,

  • Everolimus or sirolimus as the risk of angioedema may be increased.
  • Diuretics (furosemide, hydrochlorothiazide) as increases risk of low blood pressure.
  • Eplerenone, potassium-sparing diuretics (spironolactone), potassium supplements, or trimethoprim as they may increase risk of hyperkalemia (high potassium level).
  • Aliskiren or angiotensin receptor blockers (losartan) because the risk of certain side effects (kidney problems, high blood potassium levels, low blood pressure) may be increased.
  • Insulin, sulfonylureas (glipizide) and other oral diabetes medicines (metformin) as they may increases risk of low blood sugar.
  • Certain gold-containing medicines (sodium aurothiomalate) because flushing, low blood pressure, nausea, and vomiting may occur.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, indomethacin) because they may increase the risk of kidney problems and decrease Trandolapril's effectiveness.
  • Lithium or thiopurines (azathioprine) as the risk of its side effects may be increased by Trandolapril.

Other Medical Conditions

Several other conditions may reduce its effectiveness. Make sure you inform your doctor of conditions such as,

  • Heart or blood vessel problems (aortic stenosis, hypertrophic cardiomyopathy).
  • Angioedema (swelling of the face, lips, tongue, throat, arms, or legs) with other ACE inhibitors.
  • Kidney or liver diseases
  • Diabetes
  • High level of potassium and sodium in blood
  • Collagen vascular disease (an autoimmune disease).
  • if you have an autoimmune disease (rheumatoid arthritis, lupus, scleroderma)
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3 Proper Usage

Proper usage of Mavik requires strict adherence to your doctor’s orders. Mavik only helps in reducing blood pressure. It does not cure blood pressure related problems.

It is very important to continue to take medicine as directed in order to keep blood pressure within normal range. You may need to use it for the rest of your life.

With Trandolapril you should also control your weight and diet. Avoid foods which are rich in sodium (salt).

It can be taken with or without food. You should drink plenty of water while using Trandolapril.

Dosage

It is different for different patients. Dosage mentioned below is an average dose. You must follow your doctor’s instructions.

For treatment of high blood pressure

Adults: 1 to 2 milligram (mg) once a day. Your doctor may increase it to 2 to 4 mg per day.

For treatment of heart attack

Adults: Initially 1 mg per day. Your doctor may increase the dose to 4 mg per day.

Doses in children are determined by your doctor

Missed dose

If you miss a dose, take it as soon as you remember it. If it almost a time for your next dose skips the missed dose and continue your daily schedule. Do not double the dose.

Storage

Store it at room temperature. Keep it away from children.

4 Precautions to Take

In using Mavik, you must be careful and take some precautions as advised by your doctor. Your doctor should check your daily progress at regular visits.

Tell your doctor or dentist that you take Trandolapril before you receive any medical or dental care, emergency care, or surgery. Mavik can cause anaphylactic reactions.

Inform your doctor immediately if you start having:

  • rash, itching
  • fainting
  • palpitation
  • trouble breathing
  • swelling of hand face and mouth

Use an effective form of birth control methods as Trandolapril can harm an unborn baby.

It can cause intestinal angioedema. Inform your doctor immediately if you have a severe stomach pain.

You can become dehydrated easily while using Trandolapril. Inform your doctor if you are having ongoing diarrhea, vomiting as they can cause severe electrolyte imbalance and can cause death.

Trandolapril may cause:

  • drowsiness
  • dizziness
  • blurred vision
  • light-headedness

These effects may be worse if you take it with alcohol or certain medicines. Use Trandolapril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Trandolapril can cause high potassium levels in the blood. Its symptoms are:

Inform your doctor if you have any of these symptoms. Do not take any supplements which have a high level of potassium without informing your doctor.

It may alter your blood sugar levels. Keep a track on your blood sugar level. It can aggravate liver diseases.

Inform your doctor, if you notice any of these symptoms:

  • upper stomach pain
  • pale stools
  • dark urine
  • loss of appetite
  • nausea
  • unusual tiredness or weakness
  • yellow eyes or skin

5 Potential Side Effects

All medicines have some side effects. Make sure you meet with your doctor in using Mavic to avoid unwanted potential side effects.

Some people may experience none or minor side effects. Consult with your doctor if they become problematic or frequent.

More common are:

  • Cough
  • Diarrhea
  • Dizziness
  • Stomach upset
  • Blurred vision
  • Confusion
  • Difficulty with breathing
  • Sweating
  • Unusual tiredness or weakness
  • Weakness or heaviness of the legs

Less common are:

  • Abdominal or stomach cramps
  • Chest pain or discomfort
  • Cool, sweaty skin
  • Difficulty with speaking
  • Double vision
  • Inability to move the arms, legs, or facial muscles
  • Muscle cramps in the hands, arms, feet, legs, or face.
  • Seizures

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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