1 What is Megace?

Brand: Megace

Generic: Megestrol

Megace is a drug used in the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with acquired immunodeficiency syndrome (AIDS). It is also used in alleviating symptoms of advanced carcinoma of the breast or endometrium.

Megace is available as a tablet containing 20 mg or 40 mg of megestrol acetate or as a suspension containing megestrol acetate 40 milligrams in 1 milliliter.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Megestrol may interact with medications such as:

  • Dofetilide
  • Indinavir

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to megestrol
  • Adrenal gland problems such as Cushing's syndrome
  • Blood clots
  • Congestive heart failure
  • Diabetes
  • High blood pressure
  • Kidney problems
  • Unusual vaginal bleeding
  • Hyperglycemia
  • Pregnancy or lactation

2 Related Clinical Trials