1 What is Methadose?

Brand: Methadose

Generic: Methadone Hydrochloride

Methadose is a drug used in the treatment of moderate to severe pain not responsive to other drugs. This drug is also used in the detoxification and maintenance treatment of opioid addiction.

Methadose is available as a tablet containing 5 mg or 10 mg of methadone hydrochloride.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Methadose may interact with medications such as:

  • Mixed narcotic agonist-antagonists such as:
    • Pentazocine
    • Nalbuphine
    • or Butorphanol for pain
  • Narcotic antagonists such as:
    • Naltrexone
  • MAO inhibitors:
  • St. John's wort
  • Azole antifungals such as:
    • Itraconazole
  • HIV drugs such as:
    • Ritonavir
  • Macrolide antibiotics such as:
    • Erythromycin
  • Rifamycins such as:
    • Rifampin
  • Drugs used to treat seizures such as:
    • Carbamazepine
  • Alcohol
  • Allergy or cough-and-cold products
  • Medicine for sleep or anxiety such as:
    • Alprazolam
    • Diazepam
    • or Zolpidem
  • Muscle relaxants
  • Psychiatric medicines such as:

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to methadone
  • Brain disorders
  • Breathing problems
  • Kidney disease
  • Liver disease
  • Mental or mood disorders
  • Personal or family history of drug or alcohol abuse
  • Gastrointestinal problems
  • Difficulty urinating
  • Disease of the pancreas
  • Gallbladder disease
  • Certain heart problems
  • Family history of certain heart problems
  • Use of certain drugs such as:
    • Diuretics or "Water pills"
  • Severe sweating, diarrhea, or vomiting
  • Pregnancy or lactation