Methylene Blue

1 What is Methylene Blue?

Brand: Methylene Blue

Generic: Methylene Blue

Methylene blue is used in the treatment of methemoglobinemia (a condition in which blood is unable to carry oxygen). It works by converting methemoglobin to normal hemoglobin which can carry oxygen to tissues.

It is also used to treat urinary tract infection as it works by killing bacteria in the urinary tract. It may also be used as a dye to stain certain parts of the body before or during surgery.

It is available in a solution form, given only by your doctor or under his/her supervision.

Have a question aboutUrinary Tract Infections?Ask a doctor now

2 What to Know Before Using

Before using Methylene blue, you must know all about the risks and complications associated with it.


Inform your doctor if you are allergic to any food, preservatives, dyes, or had an allergic reaction when you used this drug before.


There are no adequate studies done which prove Methylene Blue effects in children. However, safety and efficacy have not been established.


There are no adequate studies done which prove Methylene Blue effects in the elderly patient.


It is a category X drug. It should not be used during pregnancy. It causes harm and abnormalities in an unborn baby.

Breast Feeding

Methylene Blue is not known if it can pass into breast milk or not. If you are using it while nursing, discuss the potential risks with your doctor.

Drug Interactions

Methylene Blue may interact with other drugs. Your doctor should be informed of any other medicines which you are taking. He may want to change the dosage or drug.
Some of them are listed below,

  • Demerol
  • Almotriptan
  • Frovatriptan
  • Naratriptan
  • Rizatriptan
  • Sumatriptan
  • Zolmitriptan
  • Carbidopa
  • Levodopa
  • Pramipexole
  • Ropinirole
  • Citalopram
  • Escitalopram
  • Fluoxetine
  • Fluvoxamine
  • Paroxetine
  • Sertraline
  • Venlafaxine
  • Desvenlafaxine
  • Duloxetine
  • Amitriptyline
  • Clomipramine
  • Desipramine
  • Doxepin
  • Imipramine
  • Nortriptyline
  • Protriptyline
  • Trimipramine
  • Bupropion
  • Buspirone
  • Maprotiline
  • Mirtazapine
  • Nefazodone
  • Trazodone
  • Vilazodone

Other Medical Problem

Several other conditions may reduce its effectiveness.

Make sure you inform your doctor of conditions such as:

  • Kidney disease
  • Glucose-6-phosphate dehydrogenase (g6pd) deficiency.

3 Proper Usage

Proper usage of Methylene blue requires strict adherence to your doctor’s orders. It is given as an injection through a needle into your vein by a nurse or by a trained health professional. It is given very slowly.

4 Precautions to Take

Before using Methylene blue, there are some precautions you must take. Your doctor should check your daily progress at regular visits.

Use an effective form of birth control methods as Methylene Blue can harm an unborn baby.

It is known to cause serious life-threatening condition called serotonin syndrome if taken with other medicines such as:

  • MAOIs
  • SNRIs
  • SSRIs
  • ergot alkaloids
  • eletriptan, sumatriptan
  • zolmitriptan
  • and antibiotics such as linezolid

Inform your doctor immediately if you have symptoms such as:

It may affect results of some medical tests.

5 Potential Side Effects

Make sure you meet with your doctor in using Methylene blue to avoid unwanted potential side effects. Some people may experience none or minor side effects.

Consult with your doctor if they become problematic or frequent:

More common are:

  • Greenish blue to blue discoloration of the urine and stools.

Less common are:

  • Diarrhea
  • Nausea and vomiting
  • Painful urination or increased need to urinate
  • Mild bladder irritation
  • Upset stomach
  • Dizziness
  • Headache
  • Increased sweating

Some serious side effects are:

  • Pain in your chest or behind your breastbone
  • Pale or blue skin
  • High fever, fast or pounding heartbeats, trouble breathing
  • Confusion, feeling like you might pass out.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

6 Related Clinical Trials