1 What is MoviPrep?

Brand: MoviPrep

Generic: Polyethylene Glycol 3350, Electrolytes, And Ascorbic Acid

The polyethylene glycol (PEG), electrolytes, and ascorbic acid combination (MoviPrep) is a prescription preparation used in cleaning the colon before a colonoscopy or other medical procedures.

It is a laxative that works by inducing diarrhea in order to clean the colon.

A clean colon is necessary to allow doctors see the inside of the colon more clearly during procedures, such as colonoscopy.

2 What to Know Before Using

Before using MoviPrep, you must know all about the risks and complications associated with it. The risks and benefits the medicine offer must be weighed.

For this medicine, you and your doctor must consider the following:


If you have any unusual reaction to any medicine, including movantik, be sure to tell your doctor about it. Additionally, disclose other types of allergies - foods, preservatives, animals, or dyes, if there are any. Read the package ingredients carefully and make sure you are not allergic to any of its ingredients.


Safety and efficacy of use are not established since no appropriate studies are performed.


Studies show that age doesn’t affect the usefulness of MoviPrep in the elderly.


It is not determined whether the drug will cause an adverse effect in fetuses or the pregnant women.


Although there are no adequate studies in lactating mothers that determine potential risk in an infant when breastfeeding, the potential benefits should be weighed against the risks before taking this medication.

Drug Interactions

Certain medicines have adverse effects when used together. Nevertheless, it is still possible to take other medicines when using this preparation. Make sure to inform your doctor about other drugs you are taking, so that alterations and precautions will be made if necessary.

Using it with certain medicines, such as

  • atropine
  • amantadine
  • belladonna
  • alkaloids
  • biperiden
  • benztropine
  • darifenacin
  • clidinium
  • eplerenone
  • dicyclomine
  • fesoterodine
  • glycopyrrolate
  • methscopolamine
  • hyoscyamine
  • oxybutynin
  • scopolamine
  • trihexyphenidyl
  • procyclidine
  • solifenacin
  • tolterodine
  • trospium

needs utmost caution because the combination may result in certain side effects. Before taking this drug, talk to your doctor about possible interactions if you are taking other medications, both prescription and over-the-counter.

Other Medical Problems

Inform your doctor about any existing or history of any other medical problems. The presence of these may affect how you use this drug.

Tell your doctor about any other medical conditions, especially:

3 Proper Usage

To use MoviPrep properly, you must follow all instructions given by your doctor. Changing your dose and adjusting the time of intake may result in increased chance of side effects. Take this medicine as directed or the medical procedure that you are going to have may not give the results you need.

It is advisable to not eat any solid food before medication and until the colonoscopy (or any other procedure). Drinking clear liquids, such as water, strained lemonade, clear fruit juices, tea, coffee, broth, gelatin, popsicles, or soda is allowed before taking the medicine, during medication, and up to 2 hours before the procedure. Do not take anything colored red or purple.

Before using MoviPrep, the powder is mixed thoroughly with lukewarm water. The mixed solution must be used within 24 hours. The solution may be chilled in the refrigerator before drinking. The solution is taken 8 ounces at a time, with intervals of 15 minutes, until all your mixture is consumed.

About an hour after drinking your first glass, you should have your first diarrhea or loose stool. Bloating or stomach upset is normal as the movement starts. If you can’t swallow the solution, inform your doctor immediately. You need to drink about 64 ounces or 2 liters of the solution plus 1 liter of clear liquid before the procedure.

Consuming the solution may be done in several ways

Split-dose method. It is a 2-day regimen, in which you drink the first liter of solution and 500 ml of clear liquid the night before the procedure. You will drink the second liter of the solution and 500 ml of clear liquid on the morning of the test or at least 2 hours prior the test.

Evening only method. At around 6pm the night before the test, drink the first liter of the solution within an hour. After one and a half hours, drink the second liter within an hour. Drink one more liter of clear liquid at the same night.

Note: Unless your doctor tells you otherwise, do not drink or eat anything 2 hours before your colonoscopy.


Follow your doctor’s orders when it comes to dosage. The number of doses, the number of hours between doses, and how long you will take this drug depend on your health condition, your progress, and how well you react to this medicine.


Keep the medicine in an airtight container at normal room temperature. Keep it away from direct light, heat, and moisture. Do not let it freeze. Keep the medicine out of children’s reach. Throw away any outdated medicine or medicine that are not in use. Keep the medicine in its original package until needed. Mixed solution can be refrigerated and must be used within 24 hours.

4 Precautions to Take

In using MoviPrep, you must be careful and take some precautions as advised by your doctor. Close monitoring is important to see if any problems will come up upon taking this medicine.

Call your doctor right away if any of the symptoms of dehydration (dizziness, headache, decreased urination, or vomiting) are present.

This may mean you have lost too much body fluid. Do not take any oral medicine 1 hour before taking the solution. Do not take any other drugs while drinking or have recently taken this solution unless advised by your doctor.

5 Potential Side Effects

While not all people taking MoviPrep may suffer from these side effects, you may need to call your doctor if any of these are present:

  • stomach pain
  • Full or bloated feeling
  • pain in the upper stomach
  • swelling of the stomach or abdominal area
  • pressure in the stomach
  • vomiting
  • Confusion
  • Coma
  • convulsions
  • dizziness
  • decreased urine output
  • dry mouth
  • Headache
  • increased thirst
  • fast or irregular heartbeat
  • unusual tiredness or weakness
  • loss of appetite
  • numbness in the feet, hands, fingertips, mouth, or lips
  • muscle pain or cramps
  • swelling of the face, hands, or ankles
  • shortness of breath

Some of the side effects may take place and may not need special medical attention and usually go away as the body adjusts to the medicine during treatment.

Some patients may experience other side effects not listed above. If you want to report side effects, you may do so by calling the FDA at 1-800-FDA-1088.

6 Related Clinical Trials