1 What is Nardil?

Brand: Nardil

Generic: Phenelzine

Nardil is a prescription drug used in treating certain depression types. It is a MAOI or monoamine oxidase inhibitor that works by blocking the action of monoamine oxidase, a chemical substance in the nervous system.

While Nardil is very effective on some patients, some may experience unwanted side effects if taken the wrong way. Your doctor may advise you to avoid taking certain medicines and some foods and beverages during treatment.

2 What to Know Before Using

If you are about to start Nardil, speak with your doctor about what you need to know. The risks and benefits the medicine offer must be weighed.

Before using this medicine, you and your doctor must consider the following:

  • Allergies: If you have any unusual reaction to any medicine, including montelukast, be sure to tell your doctor about it. Additionally, disclose other types of allergies - foods, preservatives, animals, or dyes, if there are any. Read the package ingredients carefully and make sure you are not allergic to any of its ingredients.
  • Pediatric: Safety and efficacy of use in children are not yet established.
  • Geriatric: Studies show that using phenelzine at old age doesn’t limit the usefulness of the drug. Utmost caution is required, however, since elderly patients are more likely to suffer from age-related health issues, such as kidney problems. Dosage adjustment may be required.
  • Breastfeeding: Although there are no adequate studies in lactating mothers that determine potential risk in an infant when breastfeeding, the potential benefits should be weighed against the risks before taking this medication.
  • Drug Interactions: Certain medicines have adverse effects when used together. Nevertheless, it is still possible to take other medicines when taking this drug. Make sure to inform your doctor about other drugs you are taking, so that alterations and precautions will be made if necessary.Using this with certain medicines needs utmost caution because the combination may result in certain side effects. Before taking this drug, talk to your doctor about possible interactions if you are taking other medications, both prescription and over-the-counter.
  • Other interactions: This drug interacts with certain foods, beverages, and drugs. Your doctor may provide a list of foods, beverages, and drugs to avoid.
  • Other medical conditions: If any other medical problem is present, it may impact the use of this drug.Inform your doctor about any other medical problems you have, especially congestive heart failure, bipolar disorder, severe kidney disease, history of liver disease, pheochromocytoma, hypotension, diabetes, or schizophrenia. Taking this drug can make these conditions worse.

3 Proper Usage

To use Nardil properly, you must follow all instructions given by your doctor. Do not increase the dose, take it more often, or prolong the treatment period ordered by the doctor.

Increasing the dosage without your doctor’s advice may heighten the chance of unwanted side effects, particularly in elderly patients.


For treating depression in adults, initial dosage may be given at 15 mg three times a day. Dosage may be adjusted as per your doctor’s advice, but should not exceed 90 mg a day.

Missed Dose

Take the missed dose as soon as possible. In case it is almost time for the next dose, skip the missed one and follow your regular dosing schedule. Never take double doses.


Keep the medicine in an airtight container at normal room temperature. Keep it away from direct light, heat, and moisture. Do not let it freeze. Keep the medicine out of children’s reach.

Throw away any outdated medicine or medicine that is not in use. Keep the medicine in its original package until needed.

4 Potential Side Effects

While not all people taking Nardil may suffer from these side effects, you may need to call your doctor if any of these are present:

  • Cold sweats
  • Chills
  • Faintness, dizziness, or lightheadedness when getting up from a lying or sitting position
  • Shakiness in the arms, hands, legs, or feet
  • Overactive reflexes
  • Swelling
  • Sudden jerky movements of the body
  • Trembling or shaking of the feet or hands
  • Stomach or abdominal pain
  • Out of control actions
  • Itching, burning, crawling, prickling, numbness, "pins and needles", or tingling feelings
  • Clay-colored stools
  • Change in consciousness
  • Decrease in frequency of urination
  • Dark urine
  • Decrease in urine volume
  • Troubled breathing
  • Disorganized thoughts
  • Difficulty in passing urine or dribbling
  • Dizziness
  • False or unusual sense of well-being
  • Drowsiness
  • Irregular, fast, or pounding heartbeat
  • Fear or nervousness
  • General feeling of discomfort, illness, or weakness
  • Fever
  • Headache
  • Increased sweating
  • High blood pressure
  • Irregular or shallow breathing
  • Loud or fast speech
  • Appetite loss
  • Itching
  • Irritability
  • Restlessness
  • Lack of emotion or feelings
  • Loss of consciousness
  • Nausea or vomiting
  • Low blood pressure
  • Muscle twitching
  • Shakiness and unsteady walk
  • Muscle tremors
  • No emotion or expression in speech
  • Uncontrolled eye movements
  • Unusual weakness or tiredness
  • Nervousness
  • Painful urination
  • Rapid, deep, or shallow breathing
  • Pale or blue lips, fingernails, or skin
  • Rash
  • Hallucinations
  • Seizures
  • Talking, feeling, and acting with excitement
  • Unpleasant breath odor
  • Problems with muscle control, such as unsteadiness or trembling
  • Unusual paleness
  • Vomiting of blood
  • Yellowing of the skin or eyes

Some of the side effects may take place and may not need special medical attention and usually go away as the body adjusts to the medicine during treatment.

Some patients may experience other side effects not listed above. If you want to report side effects, you may do so by calling the FDA at 1-800-FDA-1088.

5 Related Clinical Trials