1 What is Neoprofen?

Brand: Neoprofen

Generic: Ibuprofen Lysine

Neoprofen is a prescription drug that is used in treating PDA or patent ductus arteriosus in premature infants weighing 1.1 to 3.3 pounds.

Patent ductus arteriosus is a heart condition in which a blood vessel does not close after birth.

The drug causes the PDA to compress, thus closing the blood vessel, which should normally occur after the baby is born.

2 What to Know Before Using

If you are about to start Neoprofen, speak with your doctor about what you need to know. The risks and benefits the medicine offer must be weighed. Before using this, you and your doctor must consider the following:


If you have any unusual reaction to any medicine, be sure to tell your doctor about it. Additionally, disclose other types of allergies - food, preservatives, animals, or dyes, if there are any. Read the package ingredients carefully and make sure you are not allergic to any of its ingredients.


Studies show that using this drug does not cause any pediatric-specific problems limiting the usefulness of this medicine in premature babies.


No adequate studies are done in pregnant women to determine if there are harmful effects of using this drug during pregnancy.


Although there are no adequate studies in lactating mothers that determine potential risk in an infant when breastfeeding, the benefits should be weighed against the risks before taking this medication.

Drug Interactions

Certain medicines have adverse effects when used together. Nevertheless, it is still possible to take other medicines when taking rifabutin. Make sure to inform your doctor about other drugs you are taking, so that alterations and precautions will be made if necessary.

Using this medicine with certain medicines needs utmost caution because the combination may result in certain side effects. Before using this drug, talk to your doctor about possible interactions if you are taking other medications, both prescription and over-the-counter.

Other medical problems

Using this medicine may be impossible, or may need special care if the patient has certain medical problems. Ibuprofen lysine should not be administered in babies with active bleeding, blood clotting problem, congenital heart disease, kidney problem, necrotizing enterocolitis, or infection. If the baby has hyperbilirubinemia, using this drug may possibly worsen the condition.

3 Proper Usage

To use Neoprofen properly, you must follow all instructions given by your doctor.

Neoprofen is only given by a trained health professional while the patient is confined in a hospital. It is injected in one of the veins.

Increased fluid intake is advised when using this drug to help keep the kidneys on top shape and prevent kidney problems.

4 Precautions to Take

Before using Neoprofen, there are some precautions you must take. Using Neoprofen may cause the body to react differently during an infection.

If the baby develops fever, chills, or any unusual behavior during treatment, inform your doctor right away.

Moreover, the use of this drug may also affect the activity of platelets that are necessary for blood clotting, thus increasing the infant’s risk of bleeding.

If you see any signs of bleeding, such as unusual bruising or bleeding, or dark-colored urine or stools, inform the doctor right away.

5 Potential Side Effects

Make sure you meet with your doctor in using Neoprofen to avoid unwanted potential side effects.

If any of the side effects take place, consult your doctor:

  • abdominal cramps, pain or swelling
  • black, tarry stools
  • anxiety
  • bladder pain
  • bloody or cloudy urine
  • blood in eyes
  • blue lips, fingernails, or skin
  • bumps on the skin
  • bruising or purple areas on the skin
  • burning, itching, redness, or stinging of the skin
  • cold sweats
  • Chills
  • Fever
  • coma
  • cough
  • cool, pale skin
  • irregular heartbeats
  • coughing up blood
  • decreased alertness
  • increased blood pressure
  • Skin darkening
  • decreased frequency or amount of urine
  • difficulty in breathing
  • increased hunger
  • diarrhea
  • fast heartbeat
  • high blood pressure
  • indigestion
  • nosebleeds
  • increased thirst
  • irregular, fast or slow, or shallow breathing
  • irritability
  • loss of appetite
  • joint pain or swelling
  • shortness of breath
  • muscle cramps in hands, arms, feet, legs, or face
  • nausea or vomiting
  • muscle twitching
  • nervousness
  • the passing of gas
  • Skin rashes
  • rapid, shallow breathing
  • seizures
  • restlessness
  • shakiness
  • sneezing
  • pain or feeling of discomfort in the stomach
  • Swollen face, feet, lower legs, or fingers
  • tremor
  • unusual bruising or bleeding
  • troubled breathing with exertion
  • unusual tiredness or weakness

Some of the side effects may take place and may not need special medical attention and usually go away as the body adjusts to the medicine during treatment.

Some patients may experience other side effects not listed above. If you want to report side effects, you may do so by calling the FDA at 1-800-FDA-1088.