Nexium IV

1 What is Nexium IV?

Brand: Nexium IV

Generic: Esomeprazole

Nexium IV injection is a proton pump inhibitor used for the treatment of hyperacidity in the stomach. This drug can be used for the short-term treatment of gastroesophageal reflux disease (GERD) with erosive esophagitis in adults and children 1 month of age and older.

The risk of rebleeding in patients with acute gastric or duodenal ulcer after endoscopy is reduced when taking this drug. This drug works by inhibiting the H+/K+-ATPase pump in parietal cells resulting decreased amount of acid that is produced by the stomach. This drug requires a prescription.

2 What to Know Before Using

Before using Nexium IV, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children have not reported any pediatric-specific problems that would limit the utility of esomeprazole injection. Safety and efficacy of this drug in children younger than 1 month of age have not been established. Studies in the elderly have not reported any geriatric-specific problems that would limit the utility of esomeprazole injection.

Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. Infant risk is still undetermined when taking this drug during breastfeeding.

Discuss with your healthcare professional about the risks and benefits of this drug before breastfeeding. Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as Rilpivirine, Atazanavir, Bosutinib, Cilostazol, Citalopram, Clopidogrel, Dabrafenib, Dasatinib, Erlotinib, Eslicarbazepine, Acetate, Gefitinib, Ketoconazole, Ledipasvir, Methotrexate, Mycophenolate, Mofetil, Nelfinavir, Nilotinib, Pazopanib, Posaconazole, Saquinavir, Tacrolimus, Thiopental, Vismodegib, Cranberry, Levothyroxine, Risedronate, or Warfarin.

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. Inform your healthcare provider for any other medical problems such as diarrhea, hypomagnesemia, osteoporosis, or liver disease.

3 Proper Usage

Proper usage of Nexium IV requires strict adherence to your doctor’s orders. A trained health professional will be the only one allowed to give you or your child this drug in a clinic or hospital. This drug is administered intravenously through a needle placed in one of your veins.

Antacids may be given with this drug for relief as this drug may take several days to be effective. You will be switched you to an oral drug that works the same way when your condition improves. Consult with your healthcare professional for any concerns.

4 Precautions to Take

Before using Nexium IV, there are some precautions you must take. Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug.

Unwanted effects can be screened using blood tests. Check with your healthcare professional if your condition does not improve, or if it becomes worse.

Seek medical attention immediately if you experience symptoms of anaphylaxis such as rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this drug.

Check with your healthcare professional immediately if you symptoms of atrophic gastritis such as burning feeling in the chest or stomach, indigestion, stomach upset, or tenderness in the stomach area.

Check with your healthcare professional immediately if you have symptoms of acute interstitial nephritis such as fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after receiving this drug.

Check with your healthcare professional at once if you have watery diarrhea that does not go away, stomach pain, and a fever while receiving this drug. Patients 50 years of age, receiving high doses or prolonged doses of this drug may have increased the risk of having fractures of the hip, wrist, and spine.

Prolonged use of this drug for more than 1 year or using it with digoxin or diuretics may cause hypomagnesemia which manifests as convulsions, fast, racing, or uneven heartbeat, muscle spasms, tremors, or unusual tiredness or weakness. Inform your healthcare professional that you are taking this drug as it may affect the results of certain medical tests.

Consult with your healthcare professional before taking any other prescription or non-prescription drugs and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Nexium IV. Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • black, tarry stools bloody stools
  • fever
  • vomiting of blood or material that look like coffee grounds
  • drowsiness
  • loss of appetite
  • mood or mental changes
  • muscle spasms or twitching
  • nausea or vomiting
  • seizures
  • trembling
  • unusual tiredness or weakness
  • blistering, peeling or loosening of the skin
  • bloating
  • chills
  • cough
  • darkened urine
  • the difficulty with swallowing
  • dizziness
  • fast heartbeat
  • indigestion
  • joint or muscle pain
  • pains in the stomach, side or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red skin, lesions, often with a purple center red
  • irritated eyes
  • shortness of breath
  • skin rash, hives or itching
  • a sore throat
  • sores, ulcers or white spots in the mouth or on the lips
  • tightness in the chest
  • vomiting
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

6 Related Clinical Trials