1 What is Norpramin?

Brand: Norpramin

Generic: Desipramine Hydrochloride

Norpramin is a drug used for the treatment of depression. This drug is available as a film-coated tablet containing 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, or 150 mg of desipramine hydrochloride.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Norpramin may interact with medications such as:

  • Arbutamine
  • Disopyramide
  • Sibutramine
  • MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine)
  • Anticholinergics such as atropine, belladonna alkaloids, scopolamine, and drugs for Parkinson's disease such as benztropine
  • Inhaled bronchodilators such as albuterol or salmeterol
  • Certain drugs for high blood pressure such as clonidine, guanadrel, guanethidine, or reserpine
  • Digoxin
  • Nasal decongestants such as epinephrine and phenylephrine
  • Levodopa
  • Lithium
  • Stimulants such as amphetamine, epinephrine, and methylphenidate
  • Thyroid supplements
  • Valproic acid
  • Drugs affecting liver enzymes that remove desipramine from your body such as alcohol, barbiturates (phenobarbital)
  • Cimetidine
  • Cisapride
  • Haloperidol
  • Certain drugs for heart rhythms such as flecainide or propafenone
  • Halofantrine
  • HIV protease inhibitors such as amprenavir or fosprenavir
  • Phenothiazines such as thioridazine
  • Pimozide
  • Certain anti-seizure drugs such as carbamazepine or phenytoin
  • Antidepressants such as duloxetine, fluoxetine, fluvoxamine or trazodone
  • St. John's wort
  • Terbinafine
  • Amiodarone
  • Dofetilide
  • Pimozide
  • Procainamide
  • Quinidine
  • Sotalol
  • Sparfloxacin
  • Macrolide antibiotics such as erythromycin
  • Bupropion
  • Isoniazid (INH)
  • Theophylline
  • Tramadol
  • Certain antihistamines (diphenhydramine)
  • Anti-anxiety drugs (diazepam)
  • Anti-seizure drugs (levetiracetam)
  • Drugs for motion sickness (meclizine)

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

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