Nov-Onxol

1 What is Nov-Onxol?

Brand: Nov-Onxol, Onxol, Paclitaxel Novaplus, Taxol

Generic: Paclitaxel

Nov-Onxol injection is an antineoplastic drug used for the treatment of advanced cancer of the ovaries, breast, non-small cell lung cancer, and Kaposi sarcoma commonly found in patients with acquired immunodeficiency syndrome. This drug interferes with the growth of cancer cells. The growth of normal body cells may also be affected.

Discuss with your healthcare professional about the risks and benefits of taking this drug before you begin treatment with it. This drug is to be administered only by or under the immediate supervision of your healthcare professional.

2 What to Know Before Using

Before using Nov-Onxol, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children regarding the correlation of age to the effects of paclitaxel injection have not been performed while safety and efficacy have not been established. Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of paclitaxel injection.

Adjustments in the dose of the elderly may be required since they are more likely to have unwanted side effects such as heart disease, bone marrow problems, and nerve problems.

Risks to the fetus have been reported in studies pregnant women but these may be outweighed by the benefits of therapy in a life threatening situation or a serious disease. Infant risk is still undetermined when using this drug during breastfeeding.

Discuss with your healthcare professional about potential risks and benefits of taking this drug while breastfeeding. Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as:

  • Live Rotavirus Vaccine
  • Abiraterone
  • Live Adenovirus Vaccine Type 4
  • Live Adenovirus Vaccine Type 7
  • Aprepitant
  • Live Bacillus of Calmette and Guerin Vaccine
  • Bexarotene
  • Blinatumomab
  • Ceritinib
  • Cisplatin
  • Crizotinib
  • Dabrafenib
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Ethinyl Estradiol
  • Fluconazole
  • Fosaprepitant
  • Golimumab
  • Idelalisib
  • Infliximab
  • Live Influenza Virus Vaccine
  • Ketoconazole
  • Live Measles Virus Vaccine
  • Live Mumps Virus Vaccine
  • Nilotinib
  • Pazopanib
  • Piperaquin
  • Pixantrone
  • Live Poliovirus Vaccine
  • Live Rubella Virus Vaccine
  • Secukinumab
  • Siltuximab
  • Smallpox Vaccine
  • St John's Wort
  • Testosterone
  • Tretinoin
  • Typhoid Vaccine
  • Valspodar
  • Varicella Virus Vaccine
  • Yellow Fever Vaccine
  • Dalfopristin
  • Epirubicin
  • Fosphenytoin
  • Lapatinib
  • Phenytoin
  • Quinupristin

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as:

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3 Proper Usage

To use Nov-Onxol properly, you must follow all instructions given by your doctor. Cancer drugs are very potent and can have many unwanted effects. Discuss with your healthcare professional about the risks and benefits of this drug before starting treatment with it.

A trained healthcare professional will give you this drug in a hospital or cancer treatment center. This drug is administered intravenously through a needle placed in one of your veins.

This drug is usually given every 3 weeks and is used together with other cancer drugs, such as cisplatin or doxorubicin. You will be given other drugs to help prevent allergic reactions and nausea or vomiting from paclitaxel.

4 Precautions to Take

Before using Nov-Onxol, there are some precautions you must take. Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug.

Unwanted effects can be screened using blood tests. This drug has teratogenic potential and it is recommended to use effective forms of birth control to prevent pregnancy during treatment with this drug. Inform your healthcare professional immediately if you think you have become pregnant while using this drug.

Seek immediate medical attention if you experience symptoms of anaphylaxis such as a cough, dizziness, wheezing, trouble with breathing, chest or throat tightness, swelling in your face or hands, fever, chills, rash, itching or hives, skin redness, or lightheadedness or faintness while you are receiving this drug.

Having any immunizations while you are during and after treatment with this drug is not recommended to prevent any chance of acquiring the infection the vaccine is meant to prevent.

It is recommended to avoid any form of contact with people who just received live virus vaccines such as measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella to prevent any chance of acquiring these infections.

This drug can cause leukopenia and thrombocytopenia which can increase your risk of infection or bleeding. You will be advised to avoid people with infections.

Check with your healthcare professional immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Check with your healthcare professional immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.

Be careful when using a regular toothbrush, dental floss, or toothpick. You will be recommended other ways clean your teeth and gums. Check with your healthcare professional before having any dental work done.

Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur. This drug may cause peripheral neuropathy.

Check with your healthcare professional right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet while using this drug.

Cancer drugs can cause diarrhea, nausea, or vomiting in most people, sometimes even after receiving drugs to prevent it. Ask your health care professional or nurse about other ways to control these unwanted effects if you still have nausea or vomiting after receiving the drug.

Consult with your healthcare professional before taking any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Nov-Onxol. Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • Black or tarry stools
  • Blurred vision
  • Burning, Numbness, Tingling, or Painful sensations
  • Confusion
  • A cough or Hoarseness with fever or chills
  • Dizziness, Faintness, or Lightheadedness when getting up suddenly from a lying or sitting position
  • Feeling of warmth
  • Fever or Chills
  • Lower back or side pain
  • Painful or Difficult urination
  • Pale skin
  • Redness of the face, neck, arms, and occasionally upper chest
  • Shortness of breath
  • Skin rash or Itching
  • Sore throat
  • Sweating
  • Troubled breathing with exertion
  • Ulcers, Sores, or White spots in the mouth
  • Unsteadiness or Awkwardness
  • Unusual bleeding or Bruising
  • Unusual tiredness or Weakness
  • Weakness in the arms, hands, legs, or feet
  • Blood in the urine or stools
  • Difficult or labored breathing
  • Pinpoint red spots on the skin
  • Shortness of breath
  • Slow heartbeat
  • Tightness in the chest
  • Wheezing
  • Anxiety
  • Blue lips, fingernails, or skin
  • Difficult or troubled breathing
  • Fainting
  • Fast heartbeat
  • Irregular, fast or slow, or shallow breathing
  • Sudden shortness of breath

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

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