1 What is Novoseven?

Brand: Novoseven, NovoSeven RT

Generic: Coagulation Factor VIIa

Novoseven is a homeostatic factor used to treat and prevent bleeding episodes in patients with Hemophilia A or B, acquired hemophilia, congenital Factor VII deficiency, or Glanzmann's thrombasthenia. 

This drug is synthetically produced to replicate the naturally occurring activated factor VIIa in the body. This drug prevents bleeding by helping the blood to clot. 

Factor VIIa is to be given only by or under the direct supervision of your healthcare professional.

2 What to Know Before Using

Before using Novoseven, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. 

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in children have not demonstrated pediatric-specific problems that would limit the usefulness of Factor VIIa. 

Studies on the relationship of age to the effects of Factor VIIa in geriatric patients have not been performed. Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. 

Studies in women have not determined any infant risk when taking this drug during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Discuss with your healthcare professional the possible risks and benefits before taking this drug while breastfeeding. 

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects. Inform your healthcare professional if you are taking any other drugs such as Factor XIII Prothrombin Complex. 

Inform your healthcare professional if you are taking any other prescription or non-prescription drugs. Intake of specific food or using alcohol or tobacco with magnesium is associated with an increased risk of certain side effects. 

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. Inform your healthcare provider for any other medical problems such as blood clots, heart disease, infection, Injury, or liver disease.

3 Proper Usage

Proper usage of Novoseven requires strict adherence to your doctor’s orders. A trained health professional will be the only one allowed to give you this drug. This drug is administered intravenously through a needle placed in one of your veins.

4 Precautions to Take

Before using Novoseven, there are some precautions you must take. Your health care provider should closely monitor the effectiveness of this drug as well as check for unwanted effects. Unwanted effects may be screened using blood tests. 

Contact emergency medical services immediately if you experience symptoms of anaphylaxis such as rash, itching skin, difficulty with swallowing, dizziness, a fast heartbeat, lightheadedness or fainting, restlessness, trouble breathing, swelling of your face, hands, tongue, or throat, or chest pain

This drug may increase your risk of having blood clotting problems especially in people who have disseminated intravascular coagulation (DIC) or severe artery disease, or who are taking blood clotting drug. 

If you experience sudden or a severe headache, problems with vision or speech, chest pain, shortness of breath, or numbness or weakness while taking this drug, consult with your healthcare professional immediately.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Novoseven. Side effects may vary for each individual and prompt medical attention should be given if they occur. 

Inform you healthcare provider immediately if you experience any unusual symptoms such as: 

  • bleeding problems
  • fever
  • high blood pressure
  • joint or muscle pain or stiffness
  • bloating or swelling of the face, hands, lower legs, or feet
  • bluish color of the hands or feet
  • blurred vision
  • changes in facial color
  • chest pain
  • chills
  • cold sweats
  • confusion
  • continuing thirst
  • cough
  • dizziness
  • excessive sweating
  • faintness
  • fast heartbeat
  • hives
  • itching or skin rash
  • large flat blue or purplish patches on the skin
  • lightheadedness when getting up suddenly from a lying or sitting position
  • persistent bleeding or oozing from puncture sites or mucous membranes
  • puffiness or swelling of the eyelids or around the eyes
  • shakiness
  • slow or irregular heartbeat
  • slurred speech
  • sneezing
  • sore throat
  • sudden decrease in the amount of urine
  • swelling of the face, fingers, feet, or lower legs
  • troubled breathing
  • tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain

Some side effects may occur that usually do not need medical attention. As your body adjusts to the drug, these side effects may eventually disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects. 

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

6 Related Clinical Trials