1 What is Noxafil?

Brand: Noxafil

Generic: Posaconazole

Noxafil is a triazole antifungal drug used for the prevention of certain fungal infections in patients who have are immunocompromised.

This drug is to be given only by or under the direct supervision of a healthcare professional.

Have a question aboutFungal Infections?Ask a doctor now

2 What to Know Before Using

Before using Noxafil, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children regarding the correlation of age to the effects of posaconazole injection have not been performed while safety and efficacy have not been established. Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of posaconazole injection.

Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. Infant risk is still undetermined when using this drug during breastfeeding.

Discuss with your healthcare professional about potential risks and benefits of taking this drug while breastfeeding. Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drug such as:

  • Immunosuppressants metabolized by CYP3A4
  • HMG-CoA Reductase Inhibitors primarily metabolized through CYP3A4
  • Ergot Alkaloids
  • Benzodiazepines metabolized by CYP3A4
  • Anti-HIV drugs
  • Gastric Acid Suppressors/Neutralizers
  • Glipizide
  • Digoxin
  • Calcium Channel Blockers metabolized by CYP3A4
  • Vinca Alkaloids
  • Phenytoin
  • Rifabutin
  • CYP3A4 substrates

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as heart disease, heart rhythm problems, liver disease, mineral imbalance, or kidney disease.

3 Proper Usage

Proper usage of Noxafil requires strict adherence to your doctor’s orders. A trained healthcare professional will be the only one to give you this drug in a hospital.

This drug is administered intravenously through a needle placed in one of your veins. The drug must be injected slowly, so your IV tube will need to stay in place for 30 to 90 minutes. Ask your healthcare professional if you have any concerns.

4 Precautions to Take

Before using Noxafil, there are some precautions you must take. Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug. Unwanted effects can be screened using blood tests.

It is not recommended to use atorvastatin (LipitorВ®), lovastatin (MevacorВ®), pimozide (OrapВ®), quinidine (QuinagluteВ®), simvastatin (ZocorВ®), sirolimus (RapamuneВ®), or ergotamine drugs (eg, bromocriptine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, methysergide, CafergotВ®, ErgomarВ®, WigraineВ®) with this drug to prevent any chance of unwanted effects.

Contact your healthcare professional immediately if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Check with your healthcare professional immediately if you have symptoms of a serious liver problem such as pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow skin or eyes.

Check with your healthcare professional immediately if you have severe diarrhea or vomiting while using this drug. Consult with your healthcare professional before taking any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Noxafil. Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • black, tarry stools
  • blurred vision
  • decreased urine
  • dizziness
  • fever or chills
  • headache
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood or mental changes
  • muscle pain or cramps
  • muscle spasms or twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red spots on the skin
  • pounding in the ears
  • slow or fast heartbeat
  • swelling of the hands, ankles, feet, or lower legs
  • trembling
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.