1 What is Nydrazid?

Brand: Nydrazid

Generic: Isoniazid

Nydrazid is an antibiotic primarily used to treat tuberculosis. Doctors prescribe Nydrazid to treat patients with active and inactive (positive skin or lab test with no symptoms) tuberculosis.

Nydrazid is also used with other medications to treat infections caused by Mycobacterium avium Complex (MAC), Mycobacterium kansasii and Mycobacterium xenopi.

For treating tuberculosis and multi-drug resistant tuberculosis (MDR-TB), Isoniazid is always given with other anti-TB drugs like Rifampin, Pyrazinamide or Ethambutol.

Isoniazid is often an important part of treatment in many tuberculosis eradication campaigns. In that case, you may have to take Isoniazid and other anti-TB drugs under the direct supervision of health professionals.

Isoniazid is available in solution or tablets for oral consumption and as an injection. You need a doctor’s prescription to purchase Isoniazid.

Isoniazid is associated with severe liver problems especially in certain populations and patients with a history of liver diseases, which may occur during and several months after the last time the drug was taken. Only use Isoniazid according to doctor’s instructions.

2 What to Know Before Using

Before using Nydrazid, you must know all about the risks and complications associated with it. If you experienced previous reactions or allergies to Nydrazid, tell it to the doctor right away. You cannot use Nydrazid if you are allergic to it. Tell all your health problems before using Nydrazid.

Nydrazid is not recommended for patients with the following conditions:

  • Active or ongoing liver disease
  • History of having hepatitis or other liver problems caused by taking Isoniazid
  • History of having side effects due to use of Isoniazid

Tell the doctor if you have the following health conditions before receiving Nydrazid:

  • Any disease in the liver
  • Kidney disease
  • Problems in the nerves that cause symptoms such as pain, weakness or numbness
  • Diabetes
  • HIV or AIDS
  • If you drink alcohol every day
  • If you are malnourished
  • If you use any medications that are injected
  • If you previously used Isoniazid and stopped prematurely for any reason

Isoniazid is known to cause liver damage especially in patients aged 35 years and older, women especially after childbirth, women belonging to Hispanic or African-American ethnicities. Isoniazid can be used on children and infants.

If you are receiving Isoniazid, you may need to reduce or avoid foods rich in tyramine and histamines. Tyramine can cause dangerously high blood pressure levels when taken with Isoniazid. Foods high in tyramine include hard cheeses, cured meats, processed meats, pickled or fermented items, soy and soy sauces, beans, dried or overripe fruits and alcoholic beverages.

If you are receiving Isoniazid, eating foods high in histamines may cause:

You may have to avoid high-histamine foods such as fermented and pickled foods, sardines, cheese, cured meats, and bread. Tell the doctor if you are pregnant or breastfeeding before receiving Isoniazid.

Isoniazid is an FDA pregnancy category C drug, which means the medication is proven to cause harm to unborn babies when given to pregnant patients. Isoniazid can be expressed in breast milk so you must not nurse a baby while taking the medication.

3 Proper Usage

To use Nydrazid properly, you must follow all instructions given by your doctor. Nydrazid is usually given in oral tablets or solutions that you take by mouth. The injectable form of Nydrazid is given to patients that cannot take oral medications.

You must take Isoniazid on an empty stomach, 1 hour before 2 hours after a meal.

If you are taking antacids, take Isoniazid first and wait for at least an hour before taking antacids.

Always use Isoniazid and other prescribed anti-TB medications according to doctor’s instructions. Finish the whole treatment course. Skipping or stopping treatment prematurely can cause the tuberculosis bacteria to become resistant to Isoniazid and become harder to treat.

The doctor will order lab tests from time to time to see if the medicine is working and check for early signs and symptoms of side effects.

If you missed a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and stick to scheduled dosage. Do not double dose to make up for the missed dose.

If you took too much Isoniazid, call your doctor or local poison control hotlines and head to the nearest hospital immediately.

Symptoms of Nydrazid overdose include:

  • increased thirst
  • trouble breathing
  • hallucinations
  • blurred vision
  • slurred speech
  • severe drowsiness
  • vomiting
  • increased urination
  • fruity breath odor
  • loss of consciousness

Keep Isoniazid away from moisture, heat and light.

4 Precautions to Take

In using Nydrazid, you must be careful and take some precautions as advised by your doctor. If you take Nydrazid and other anti-TB medications for tuberculosis, it is very important to finish the whole course of treatment.

Isoniazid is highly irritating to the nerves. The doctor may prescribe vitamin B6 (Pyridoxine) to reduce this effect. Call your doctor if you experience symptoms such as numbness, tingling or burning sensation in the arms or feet.

Make sure to stick to scheduled clinic visits and lab tests while taking Isoniazid. This will help the doctor know if the medication is working and check for side effects.

Call the doctor immediately if your symptoms are not improving or become worse after two weeks of taking Isoniazid.

Isoniazid may change results of lab tests, so make sure your health providers know you are taking the medication.

Drinking alcohol while receiving Isoniazid can cause liver problems, which can complicate tuberculosis treatment.

Do not drink alcohol while taking Isoniazid until the doctor determines everything is okay.

Do not take any medication, including over-the-counter medications and herbal products, without call the doctor first. Taking medicines such as Acetaminophen with Isoniazid can cause damage to the liver, so take them only as directed by your doctor.

Reduce intake or avoid foods rich in tyramines and histamines while taking Isoniazid.

5 Potential Side Effects

Call your doctor if you experienced the side effects while receiving Nydrazid:

  • Serious allergic reactions such as difficulty breathing, hoarseness, hives, itching, swelling of the lips, face, mouth, and tongue
  • Signs of liver problems such as extreme tiredness, weakness, itching, fever, pain in the upper stomach, loss of appetite, passing out clay-colored stools, dark urine, and jaundice
  • Numbness, tingling or burning sensation in the hands or feet
  • Pain behind the eyes
  • Blurred vision
  • Confusion
  • Hallucinations
  • Unusual behavior
  • Seizures
  • Pale skin
  • Easy bruising and bleeding tendencies such as nosebleeds and bleeding gums
  • General feeling of illness

Nydrazid may cause the following side effects that are minor and does not harm your health:

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