1 What is Obizur?

Brand: Obizur

Generic: Antihemophilic Factor Porcine Sequence

Obizur is generally used for the treatment of serious bleeding episodes in patients with acquired hemophilia A. The bleeding episode may occur due to trauma or surgery.

Indeed, antihemophilic factor recombinant porcine sequence is a manmade protein which is preferably used to replace the AHF produced naturally in the body. It is required for clot formation and maintenance of hemostasis.

Acquired hemophilia A, also called classic hemophilia, is a clinical disorder that develops in such conditions where the body fails to make enough AHF. If you do not have enough AHF and you become injured, the clot formation will be impaired.

You might bleed into and damage your muscles and joints. That’s why this injection is given to increase the levels of AHF in the blood.

This product is available in powder form which is used for preparing a solution. You will get this drug only with your doctor's prescription.

2 What to Know Before Using

Before using Obizur, you must know all about the risks and complications associated with it. Drug therapy should be chosen with the active participation of both doctor and patient.

There are some important factors such as the presence of any metabolic impairment, history of hypersensitivity reaction, drug interactions, pregnancy, lactation etc. that may alter the desired therapeutic effects of a medicine.

Sometimes the presence of other health disorders affects the beneficial effects of this medicine and even may cause serious toxic effects. The use of this medicine is contraindicated in certain individuals who have had an anaphylactic or severe systemic reaction to antihemophilic factor or Von Willebrand factor preparations.

In addition, it is always recommended to consult with your doctor if you are in need of some other medications or even any over-the-counter medicine for another health problem in order to avoid unwanted toxic effects which may take place because of drug interactions. Here, no known drug interactions are well documented.

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-documented studies in humans. But potential benefits may warrant use of the drug in pregnant women despite potential risks.

3 Proper Usage

Proper usage of Obizur requires strict adherence to your doctor’s orders. This medicine is usually given to the patients by a nurse or other trained health professional at your doctor’s chamber, hospital, or clinic. This injection is intended for intravenous use.

The dosage schedule and the duration of drug therapy depend on the particular medical problem for which you are going to use this medicine. The therapeutic dose may also vary with the patient’s condition or requirement and the strength of the medicine as well.

In order to control bleeding in patients with hemophilia A, the therapeutic dose is determined by a healthcare professional taking into account the body weight, the type of bleeding episode and the severity of the condition.

If you miss a dose of this medicine, take it as soon as possible. But when it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Further, it is advised to store the medicine in a closed container at room temperature away from heat, moisture, and direct light. All kinds of medicines should be kept out of the reach of children. However, outdated medicines should be disposed of by an appropriate way.

4 Precautions to Take

Before using Obizur, there are some precautions you must take. Firstly, regular visits to your doctor are recommended to check the prognosis while undergoing a drug therapy. Additionally, the following guidelines should be followed:

  • Close monitoring for signs of intravenous hemolysis by a healthcare professional.
  • Certain blood tests including standard coagulation test should be carried out on a regular basis in order to measure the level of antihemophilic factor, especially in cases of surgery.
  • This medicine may cause serious types of allergic reactions like anaphylaxis. It can be life-threatening and requires immediate medical attention.
  • If you have any rash, itching, hoarseness, the problem in breathing, trouble in swallowing, lightheadedness or dizziness, or any swelling of your hands, face, or mouth after receiving this medicine contact with your doctor right away.
  • Self-medication should be avoided for this medicine.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Obizur. These side effects usually go away during the treatment episode as your body adjusts to the medicine.

Further, your healthcare professional may advise you about the ways how to prevent or reduce those unwanted side effects.

Sometimes you may need to consult with the doctor if you notice any of the following toxic effects, especially:

  • Fever
  • Chills
  • Nausea
  • Epistaxis
  • Sweating
  • Palpitation
  • Chest tightness
  • Injection site bleeding
  • Postoperative wound
  • Facial skin color change
  • Skin rash, itching or hives
  • Fast or irregular breathing
  • Lightheadedness
  • Puffiness of eyelids
  • Burning sensation
  • Numbness or tingling.
  • Redness of the skin
  • Tiredness or weakness

Other side effects not listed may also occur in some patients while undergoing this drug therapy. If any other effects are noticed, you should consult a healthcare professional for medical advice.