Onfi is a benzodiazepine used to help control seizures that occur with Lennox-Gastaut syndrome (LGS). This drug works in the brain by slowing down the nervous system to prevent seizures.
This drug will not cure LGS and will only offer symptomatic relief with continued use. This drug requires a prescription.
2 What to Know Before Using
Before using Onfi, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.
Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in children 2 years of age and older have not been performed while safety and efficacy have not been established. Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the usefulness of clobazam.
Adjustments in the dosage may be required in the elderly as they more likely to have age-related liver problems. Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. This drug poses minimal risk to infants when used during breastfeeding.
Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.
Inform your healthcare professional if you are taking any other drugs such as:
Intake of specific food or using alcohol or tobacco with magnesium is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.
Inform your healthcare provider for any other medical problems such as depression, mood or behavior disorder, or liver disease.
Proper usage of Onfi requires strict adherence to your doctor’s orders. To prevent any side effects, take this drug exactly as directed on the label or as prescribed by your healthcare professional. Follow the specific directions on the label or as directed by your healthcare professional.
This drug can be swallowed whole, halved or crushed and can be taken with or without food. Use the appropriate measuring tools when taking this drug in liquid form. The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed.
The dosage of this drug you take depends on the medical problem for which you are using this drug. Adults, teenagers, and children 2 years of age and older weighing more than 30 kilograms with seizures are dosed based on body weight and must be determined by a healthcare professional. 10 milligrams per day, given as 2 divided doses per day is usually given as a preliminary dose.
The dose must not exceed 40 mg per day. For older adults or those weighing 30 kg or less, the initial dose is usually 5 mg as a single dose per day and must not exceed 40 mg per day for older adults and 20 adults for those weighing 30 kg or less.
Use and dose in children younger than 2 years of age must be determined by your healthcare provider. A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.
Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs. Throw away any unused oral liquid 90 days after the bottle is opened for the first time.
4 Precautions to Take
Before using Onfi, there are some precautions you must take. Your health care provider should closely monitor the effectiveness of this drug as well as check for unwanted effects.
This drug can potentiate the effects of alcohol and other CNS depressants such as antihistamines or medicine for hay fever, allergies, and colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.
This drug may cause dizziness, drowsiness, or reduce normal alertness. Be careful in taking this drug before you drive, use machines, or do anything else that could be dangerous.
Your healthcare professional might slowly taper the dose of this drug before stopping it completely to prevent a possible worsening of your seizures and reduce the possibility of withdrawal symptoms such as a headache, nausea, irritability, tremors, or trouble sleeping.
Do not take more than your prescribed dose as drug dependence has been associated with this drug. Consult with your healthcare professional if you experience blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills.
Discuss with your healthcare professional if you have any unusual or strange thoughts and behavior while taking this drug. Clobazam may cause confusion, worsening of depression, hallucinations, suicidal thoughts, and unusual excitement, nervousness, or irritability especially to those who drink alcohol.
Birth control pills may not work as well while you are using this medicine. To avoid any chance of pregnancy from happening, use another form of birth control together with your birth control pills during therapy and for 28 days after you take the last dose.
Consult with your healthcare professional before taking any other prescription or nonprescription drugs, and herbal or vitamin supplements.
5 Potential Side Effects
Make sure you meet with your doctor in using Onfi to avoid unwanted potential side effects. Side effects may vary for each individual and prompt medical attention should be given if they occur.
Inform you healthcare provider immediately if you experience any unusual symptoms such as:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Ask your healthcare professional about ways to prevent or reduce some of these side effects.
If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.
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