Onmel is a medication that fights fungal infections, which are infections caused by fungi. Doctors prescribe Itraconazole to treat blastomycosis, histoplasmosis, aspergillosis, onychomycosis (fungal infection of the fingernails or toenails), particularly in patients with very weak immune systems.
Fungal infections cannot be treated with antibiotics. Fungal infections must be treated with antifungals like Itraconazole. Itraconazole, in particular, is well absorbed when taken by mouth and have strong activity against many species of disease-causing fungi. Itraconazole requires a prescription.
Itraconazole comes with a boxed warning. Itraconazole is associated with severe adverse effects in the heart and must be used with caution in patients with suspected heart diseases.
Many medications also interact with Itraconazole and cause life-threatening side effects. You must only use Itraconazole in accordance with doctor’s instructions.
Having personal or family history of long QT syndrome, a rare heart rhythm disorder
Itraconazole is a highly contraindicated in pregnant patients, so tell the doctor if you are pregnant or breastfeeding before receiving the medication. Itraconazole is an FDA pregnancy category C drug and can cause harm to the unborn baby. Do not breastfeed when having treatment with Itraconazole.
You need to tell the doctor all the medicines you are taking before receiving Itraconazole.
Certain medications are known to cause life-threatening health problems when taken with Itraconazole, such as:
Disopyramide, Dofetilide, Dronedarone, Quinidine
Felodipine and Nisoldipine
Lovastatin and Simvastatin;
Oral Midazolam, Triazolam;
Dihydroergotamine, Ergonovine, Ergotamine, and Methylergonovine
Using Itraconazole with drugs like Colchicine, Fesoterodine, Telithromycin And Solifenacin can cause toxicities in patients with certain kidney and liver conditions.
Here are drugs that can interact with Itraconazole:
Drugs indicated to treat convulsions
Strong analgesics such as Alfentanil, Buprenorphine, Fentanyl, Oxycodone, and Sufentanil
Antidiabetic drugs such as Repaglinide and Saxagliptin
To use Onmel properly, you must follow all instructions given by your doctor. The doctor will determine your dose of Onmel.
It is very important to follow your doctor’s instructions in taking Onmel and do not increase the dose or take longer than recommended to avoid adverse effects.
Itraconazole is available in capsules and solution that you take by mouth. Note that capsules and solution are not interchangeable.
If you are taking Itraconazole capsules, take them with a full meal to improve absorption. Swallow Itraconazole capsules whole, and do not break, chew, open or crush the capsules.
Itraconazole solution must be taken on an empty stomach, 1 or 2 hours before a meal. You also have to swish Itraconazole solution in the mouth for several seconds before swallowing. Always use the included dosing syringe or special dose-measuring cup or spoon in taking Itraconazole solution. If you do not have a measuring device, call your pharmacist.
If you are taking an antacid, you can take Itraconazole with a non-diet soda and other acidic drinks.
Always finish the entire course of treatment. You may start feeling better even before the infection is totally cleared. Skipping the medicine may cause the fungi to acquire resistance to Itraconazole.
If you missed a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and stick to the regular dosing schedule.
If you skipped several doses of Itraconazole, call the doctor right away. Store Itraconazole away from heat, moisture and light. Do not freeze.
4 Precautions to Take
In using Onmel, you must be careful and take some precautions as advised by your doctor. Note that you need to have regular lab tests to check your organs and blood for early signs of side effects while taking Onmel. Make sure to stick to your doctor’s schedule.
Onmel may cause hearing loss, especially if you also took Quinidine. Call your doctor right away if you experience profound hearing loss. Itraconazole may impair thinking and reflexes. Be careful when you drive or perform crucial tasks.
Note that antacid may reduce absorption of Itraconazole. You need to avoid antacids for 1 hour before or 2 hours after taking Itraconazole.
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