Oxsoralen-ultra along with ultraviolet A light is used in the treatment of vitiligo (a disease in which skin become colorless) and mycosis fungoid (white blood cell lymphoma).
Methoxsalen belongs to a group called psoralen. Methoxsalen (a psoralen) and ultraviolet A together called PUVA works by making the skin more sensitive to UV light. Sensitivity results in damage to the skin cells and so damaged skin cells grow more slowly and the rate of tissue growth is reduced.
It may also be used for other conditions such as alopecia areata, eczema, inflammatory dermatoses, lichen planus, need to increase tolerance of skin to sunlight and psoriasis.
It is available in the form of capsule and liquid filled capsule, only with your doctor’s prescription.
2 What to Know Before Using
Before using Oxsoralen-ultra, you must know all about the risks and complications associated with it.
Inform your doctor if you are allergic to any food, preservatives, dyes, or had an allergic reaction when you used this drug before.
Methoxsalen should not be used in children younger than 12 years of age. Safety and efficacy have not been established.
It should be used with caution as they may be more sensitive to its effects.
It is a category C drug. It is not safe in pregnancy. It may cause harm and abnormalities in an unborn baby.
There are no adequate studies which prove that Methoxsalen passes into breast milk or not. If you are using Methoxsalen while nursing, discuss it with your doctor for possible risk factors.
Methoxsalen may interact with other drugs. Your doctor should be informed of any other medicines which you are taking. He/she may want to change the dosage or drug. Some of them are listed below:
Other Medical Problem
Several other conditions may reduce its effectiveness.
Make sure you inform your doctor of conditions such as:
Heart or blood vessel disease
History of coal tar UV treatment
History of ionizing radiation
History of arsenic compounds or oral psoralen UVA treatment.
Adults and children 12 years of age and over: Take 20 milligram (mg) of a tablet per day two to four hours before ultraviolet light A (UVA) exposure. This combination of treatment (Methoxsalen and UVA) should be taken 2 to 3 times a week at least 48 hours apart.
For mycosis fungoid and psoriasis
Adults and children 12 years of age and over: The dose is 0.6 mg per kilogram (kg) (0.27 mg per pound) of body weight taken two hours before UVA exposure. This combination of treatment (Methoxsalen and UVA) should be taken 2 to 3 times a week at least 48 hours apart.
Adults and children 12 years of age and over: The dose is 0.4 mg per kg (0.18 mg per pound) of body weight taken one and one-half to two hours before UVA exposure. This combination of treatment (Methoxsalen and UVA) should be taken 2 to 3 times a week at least 48 hours apart.
Doses are determined by your doctor for children below 12 years of age for all above mentioned diseases.
Do not miss the dose. If you forget your dose, ask your pharmacist or doctor for instructions.
The gap between Methoxsalen and UVA is 2 to 4 hours if you are taking hard gelatin form of capsule or 1½ to 2 hours if you are taking soft gelatin form of a capsule. If this gap is not maintained, the treatment may show no improvement.
Store it at room temperature. Keep it away from children.
4 Precautions to Take
Before using Oxsoralen-ultra, there are some precautions you must take. Your doctor should check your daily progress at regular visits. He/she may want a blood or urine test to check for unwanted effects.
Avoid sun exposure for at least 24 hours before and 8 hours after the treatment. It includes indirect light through a window or on cloudy days. Wear protective clothing, or use a sunscreen with a sun protective factor (SPF) of 15 or greater, if you cannot avoid the sun.
Protect all areas of the body, including lips, from sun exposure. Use extra caution for at least 72 hours following each treatment if you plan to spend any time in the sun.
The treated area of skin becomes more sensitive to sunlight. Serious sunburn can occur even through a window glass or on cloudy days.
Protect your eyes during daylight with special wraparound sunglasses that totally block absorption of ultraviolet light at least 24 hours after you take this medicine. It protects from cataracts. Wear even in indirect light, such as light coming through window glass or on a cloudy day.
Do not use it more often than recommended by your doctor as it may cause serious sunburns, dry and itchy skin, skin cancers or premature aging of the skin.
5 Potential Side Effects
As with many medications, there are several potential side effects associated with Oxsoralen-ultra. Some people may experience none or minor side effects.
Consult with your doctor if they become problematic or frequent:
More common are:
Dryness or redness of the skin
new skin growths
Premature aging of the skin
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
FindATopDoc is a trusted resource for patients to find the top doctors in their area. Be visible and accessible with your up to date contact
information, certified patients reviews and online appointment booking functionality.