1 What is Parnate?

Brand: Parnate

Generic: Tranylcypromine

Parnate is a monoamine oxidase inhibitors used for the treatment of certain types of depression.

This drug works by blocking the action of a chemical substance known as monoamine oxidase in the nervous system. This drug may cause unwanted effects if taken the incorrect way.

Certain foods, beverages, and drugs must be avoided while you are using tranylcypromine. You will be provided a list of which products you should avoid. This drug requires a prescription.

2 What to Know Before Using

Before using Parnate, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in children regarding the correlation of age to the effects of tranylcypromine have not been performed while safety and efficacy have not been established.

Data on the correlation of age to the effects of tranylcypromine in geriatric patients are still unavailable. Adjustments in the dose of the elderly may be required since they are more likely to have age-related kidney problems.

Infant risk is still undetermined when using this drug during breastfeeding. Discuss with your healthcare professional about the potential risks and benefits of taking this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as:

  • Amitriptyline
  • Amoxapine
  • Amphetamine
  • Apraclonidine
  • Atomoxetine
  • Benzphetamine
  • Brimonidine
  • Bupropion
  • Buspirone
  • Carbamazepine
  • Carbidopa
  • Carbinoxamine
  • Citalopram
  • Clomipramine
  • Clovoxamine
  • Cyclobenzaprine
  • Cyproheptadine
  • Desipramine
  • Desvenlafaxine
  • Dexfenfluramine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan
  • Diethylpropion
  • Dopamine
  • Dothiepin
  • Doxepin
  • Doxylamine
  • Duloxetine
  • Entacapone
  • Epinephrine
  • Escitalopram
  • Femoxetine
  • Fenfluramine
  • Fluoxetine
  • Fluvoxamine
  • Furazolidone
  • Guanadrel
  • Guanethidine
  • Hydroxytryptophan
  • Imipramine
  • Isocarboxazid
  • Isometheptene
  • Levodopa
  • Levomethadyl
  • Levomilnacipran
  • Linezolid
  • Lisdexamfetamine
  • Lofepramine
  • Maprotiline
  • Mazindol
  • Meperidine
  • Mephentermine
  • Methadone
  • Methamphetamine
  • Methotrimeprazine
  • Methyldopa
  • Methylene Blue
  • Methylphenidate
  • Milnacipran
  • Mirtazapine
  • Nefopam
  • Nortriptyline
  • Opipramol
  • Pargyline
  • Paroxetine
  • Phendimetrazine
  • Phenelzine
  • Phenmetrazine
  • Phentermine
  • Phenylalanine
  • Phenylephrine
  • Phenylpropanolamine
  • Procarbazine
  • Protriptyline
  • Pseudoephedrine
  • Rasagiline
  • Reserpine
  • Rizatriptan
  • Safinamide
  • Selegiline
  • Sertraline
  • Sibutramine
  • Sumatriptan
  • Tapentadol
  • Tetrabenazine
  • Tranylcypromine
  • Trazodone
  • Trimipramine
  • Tryptophan
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Zolmitriptan
  • Altretamine
  • Avocado
  • Bitter Orange
  • Difenoxin
  • Diphenoxylate
  • Disulfiram
  • Dolasetron
  • Droperidol
  • Ephedrine
  • Ethchlorvynol
  • Fentanyl
  • Frovatriptan
  • Granisetron
  • Guarana
  • Hydrocodone
  • Hydromorphone
  • Iobenguane
  • I 123
  • Kava
  • Licorice
  • Lorcaserin
  • Ma Huang Mate
  • Metaraminol
  • Methoxamine
  • Metoclopramide
  • Morphine
  • Morphine Sulfate Liposome
  • Naratriptan
  • Nefazodone
  • Oxycodone
  • Palonosetron
  • Reboxetine
  • St John's Wort
  • Tegafur
  • Tolcapone
  • Tramadol
  • Tyrosine
  • Ziprasidone
  • Acarbose
  • Albiglutide
  • Alogliptin
  • Bromocriptine
  • Canagliflozin
  • Chlorpropamide
  • Dapagliflozin
  • Dulaglutide
  • Empagliflozin
  • Exenatide
  • Ginseng
  • Glimepiride
  • Glipizide
  • Glyburide
  • Insulin
  • Recombinant Insulin Aspart
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glulisine
  • Recombinant Insulin Lispro
  • Linagliptin
  • Liraglutide
  • Lixisenatide
  • Metformin
  • Miglitol
  • Nateglinide
  • Pioglitazone
  • Pramlintide
  • Repaglinide
  • Rosiglitazone
  • Saxagliptin
  • Sitagliptin
  • Tolazamide
  • Tolbutamide
  • Vildagliptin

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as bipolar disorder, headache, cardiovascular disease, hypertension, liver disease, pheochromocytoma, stroke, diabetes, hyperthyroidism, hypotension, or kidney disease.

3 Proper Usage

To use Parnate properly, you must follow all instructions given by your doctor. Take this drug exactly as directed on the label or as prescribed by your healthcare professional. The dose of this drug will be variable for different patients.

The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

Adults with depression are initially given 30 milligrams per day, given in divided doses. Your healthcare professional may adjust your dose if necessary. The dose must not exceed 60 mg per day.

Use in children is not recommended. A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

Before using Parnate, there are some precautions you must take. Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug. Your blood pressure will also be monitored during and after treatment with this drug.

Consult with your healthcare professional immediately if you notice any change to your recommended blood pressure. Hypertensive crisis can happen when this drug is taken with certain foods, drinks, or other drugs.

Foods that have high tyramine content such as:

  • cheese
  • caviar
  • sour cream
  • liver
  • canned figs
  • soy sauce
  • sauerkraut
  • fava beans
  • yeasts
  • yogurt
  • smoked or pickled meat
  • poultry
  • fish
  • sausage
  • pepperoni
  • salami
  • anchovies
  • herring
  • dried fruit
  • bananas
  • avocados
  • raspberries
  • or very ripe fruit should also be avoided

It is recommended to avoid alcoholic drinks such as Chianti wine, sherry, beer, non-alcohol or low alcohol beer and wine, and liqueurs, and caffeine-rich drinks such as coffee, cola, chocolate, tea, and many other foods and drinks.

Ask your health care professional how much caffeine is safe to use. This drug may cause agitation, irritability, or other abnormal behaviors such as suicidal thoughts and tendencies or depression.

Tell your healthcare professional immediately if you notice any of these adverse effects.

Call your healthcare professional or hospital emergency room immediately if you have symptoms of hypertensive crisis such as a severe headache, stiff or sore neck, chest pains, fast heartbeat, sweating, dizziness, or nausea and vomiting while you are taking this drug.

This drug may cause blurred vision or make some people drowsy or less alert than they are normal. Be careful in taking this drug before you drive, use machines, or do anything else that could be dangerous.

This drug will potentiate the effects of alcohol and other CNS depressants such as antihistamines or drug for hay fever, allergies, or colds, sedatives, tranquilizers, or sleeping drug, prescription pain drug or narcotics, a drug for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

Check with your healthcare professional before taking any of the above whiles you are using this drug. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position.

Getting up slowly may help. When you get up from lying down, sit on the edge of the bed with your feet dangling for 1 or 2 minutes, then stand up slowly. Check with your healthcare professional if the problem continues or gets worse.

Check with your healthcare professional before you stop taking this drug. Your healthcare professional may slowly taper the amount you are using before stopping it completely.

Inform the health care professional or dentist in charge that you are using this drug or have used it within the past 10 days before having any kind of surgery, dental treatment, or emergency treatment.

Taking tranylcypromine together with drugs that are used during surgery, dental, or emergency treatments may increase the risk of serious side effects.

Your healthcare professional may want you to carry an identification card stating that you are using this drug. This drug may affect blood sugar levels. If you are diabetic, be especially careful in testing for sugar in your blood or urine.

If you have any questions about this, check with your healthcare professional. After you stop using this drug, you must continue to exercise caution for at least 2 weeks with your foods, drinks, and other drugs, since these items may continue to react with tranylcypromine.

Consult with your healthcare professional before taking any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Parnate. Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • the absence of or decrease in body movement
  • actions that are out of control
  • agitation
  • anxiety
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • burning
  • crawling
  • itching
  • numbness
  • prickling
  • "pins and needles" or tingling feelings
  • chest pain
  • chills
  • coma
  • confusion
  • confusion about identity, place, and time
  • a cough or hoarseness
  • dark urine
  • the decrease in frequency of urination
  • the decrease in urine volume
  • depression
  • difficulty in passing urine
  • dizziness
  • dry mouth
  • fast, irregular, pounding or racing heartbeat or pulse
  • fever
  • fever with or without chills
  • the general feeling of tiredness or weakness
  • headache
  • hostility
  • hyperventilation
  • increased need to urinate
  • irregular heartbeats
  • irritability
  • lethargy
  • light-colored stools
  • longer than usual time to ejaculation of semen
  • loss of bladder control
  • lower back or side pain
  • muscle twitching
  • nausea and vomiting
  • nervousness
  • painful or difficult urination
  • pale skin
  • passing urine more often
  • pinpoint red spots on the skin
  • rapid weight gain
  • restlessness
  • seizures
  • shakiness and unsteady walk
  • shortness of breath
  • a sore throat
  • sores
  • ulcers, or white spots on the lips or in the mouth
  • stupor
  • sudden jerky movements of the body
  • swelling
  • swelling of the face, ankles or hands
  • swollen glands
  • talking, feeling and acting with excitement
  • trouble with sleeping
  • troubled breathing with exertion
  • unsteadiness
  • trembling or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal pain
  • yellow eyes and skin

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

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