1 What is Paser?

Brand: Paser, Pamacyl, Paramycin, Teebacin, Monopas, Q-Pas, Granupas, Sodium PAS

Generic: Aminosalicylate sodium

Paser is an antibiotic which is often used as an anti-infective. It is usually prescribed to treat tuberculosis (TB) as an anti-mycobacterial agent used with other antitubercular drugs (most often isoniazid) for the treatment of active tuberculosis.

It inhibits the development of bacterial resistance to isoniazid and streptomycin. This drug is not effective against colds, flu, or other viral infections.

In order to treat tuberculosis (TB) completely, you should not miss any dose during the treatment schedule.

You may begin to feel well after few months of therapy but it is always needed to complete the full course of such medications. 

2 What to Know Before Using

Before using Paser, you must know all about the risks and complications associated with it. This is a decision that your doctor will make with your active participation.

There are some important factors such as drug interaction, metabolic impairment, hypersensitivity reaction, pregnancy, lactation etc. which may alter the drug action.

Certain drugs (e.g. digoxin) should not be used concurrently with such medications. It is always recommended to consult with your doctor if you are in need of some drugs for another health problem.

You should not take the following drugs during aminophylline therapy in order to get rid of drug reactions. Sometimes the presence of other health disorders affects the beneficial effects of this medicine and even may cause serious complications.

Make sure you mention your doctor if you have any other medical problems, especially:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency: G6PD deficient patients should not be treated with aminosalicylate sodium to avoid further worsening of the health status.
  • Cardiovascular ailments—This medication should not be used in patients with heart failure or other cardiac problems.
  • Severe renal diseases—kidney problems interfere with excretion of aminosalicylate sodium resulting in increased toxicity and excessive unwanted adverse effects.
  • Severe hepatic disorders—use of aminosalicylate sodium is contraindicated in hepatic failure.
  • Gastric problems— Stomach irritation is aggravated when such medications are taken orally.

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Studies in breastfeeding mothers have demonstrated harmful effects to the infants. An alternative to this medicine should be prescribed or you need to stop breastfeeding for the betterment of the infant while using this medicine.

3 Proper Usage

To use Paser properly, you must follow all instructions given by your doctor. The dose of this medicine will vary according to patient’s condition or requirements.

You should follow the doctor's directions and advice. The amount of medicine that you take should not exceed the maximum therapeutic dose.

Also, the frequency of your daily drug administration and the duration of drug therapy depend on the particular medical problem for which you are taking the medicine.

Gastric irritation is reported in patients receiving aminosalicylate sodium. It is advised to take aminosalicylate sodium with or after meals.

In addition, you may take an antacid if you feel irritation in your stomach. Therapeutic administration of aminosalicylate sodium for the treatment of TB may vary according to age and/or body weight.

The treatment schedule may be extended depending on the severity of the disease. Adults and children of 12 years should take 3.3-4 grams aminosalicylate acid at every 8 hours, or 5-6 grams twice in a day.

This medicine is usually prescribed with other drugs to treat tuberculosis (TB). In the case of younger children, the therapeutic dosage and schedule are determined cautiously by the healthcare professionals.

Always try to take your medicine in time. If you miss any dose of this medicine, you should take it as soon as possible. But when it is time for your next dose, then skip the missed dose and go back to your regular dosing schedule.

You should store the medicine in a closed container at room temperature away from heat, moisture, and direct light.

4 Precautions to Take

Before using Paser, there are some precautions you must take. Regular visits are recommended to make sure this medicine is working properly or not while you are undergoing aminosalicylate sodium therapy.

Some important measures should be taken if you feel any discomfort following this drug therapy. You should tell your doctor if you are allergic to such medications or any other medicines.

You should contact your doctor immediately if you become worse. In addition, you should not take aminosalicylate sodium within 6 hours after taking rifampin.

Concurrent administration of these medicines may hamper the desired therapeutic effects of rifampin. Moreover, false test results are reported with some urine sugar tests in diabetic patients who are receiving this medicine.

Thus, you must tell your doctor if you are a diabetic patient. It helps the doctor to determine the effective therapeutic dosage and schedule.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Paser. There are some unwanted side-effects associated with each drug that usually do not need medical attention.

The common side effects of aminosalicylate sodium are nausea, vomiting, diarrhea, loss of appetite, epigastric discomfort or mild pain etc.

These side-effects usually go away during the treatment episode as your body adjusts to the medicine. Additionally, your health care professional may advise you about the ways how to prevent or reduce those unwanted side-effects.

Sometimes you may need to consult with the doctor if you feel any serious toxic effect. Sometimes the following side effects may continue for some patients with high-dose and/or long-term therapy – irregular menstruation, loss of libido in males, dry and puffy skin, unusual weight gain, and edema rarely.

6 Related Clinical Trials