1 What is Ponstel?

Brand: Ponstel

Generic: Mefenamic Acid

Ponstel is used in the treatment of mild to moderate pain. It is also used in the treatment of menstrual cramps and pain. It is NSAIDs (nonsteroidal anti-inflammatory drug).

It works by blocking certain substances which cause inflammation. Ponstel only relieves the symptoms of pain and inflammation but do not treat the disease. It is available in capsule form, only with your doctor’s prescription.

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2 What to Know Before Using

If you are about to start Ponstel, speak with your doctor about what you need to know.


Inform your doctor if you are allergic to any food, preservatives, dyes, or had an allergic reaction when you used this drug before.


There are no adequate studies done which prove its harmful effects on children. However, safety and efficacy have not been established for girls below 14 years of age.


This medicine does not cause any different side effects or problem than it does in younger adults. However, it should be used with caution in a patient with age-related kidney diseases as they may require an adjustment in doses.


It is a category C drug. It is not safe to use during pregnancy as it may cause harm to an unborn baby. Do not use it in last trimester of pregnancy (last 3 months of pregnancy). Consult your doctor and discuss the benefits and risks of using Mefenamic acid while you are pregnant.


Mefenamic acid passes into breast milk. It is safe not to breastfeed while using Mefenamic acid. If you are using Mefenamic acid while nursing, discuss it with your doctor for possible risk factors.

Drug Interactions

Mefenamic acid interacts with many drugs. It should not be used with several drugs. Your doctor should be informed of any other medicine which you are taking as he/she may change the dosage or drug. Some of them are listed below:

  • Anticoagulants (warfarin, heparin)
  • Ketorolac
  • Aspirin
  • Corticosteroids (prednisone)
  • Selective serotonin reuptake inhibitors (SSRIs) (fluoxetine)
  • Venlafaxine
  • Vilazodone
  • Magnesium hydroxide (antacids)
  • Probenecid
  • Cyclosporine
  • Lithium
  • Methotrexate
  • Quinolones (ciprofloxacin)
  • Sulfonylureas (glipizide)
  • (ACE) inhibitors (enalapril)
  • Diuretics (furosemide, hydrochlorothiazide)

Other Medical Conditions

Several other conditions may reduce its effectiveness.

Make sure you inform your doctor of conditions such as:

3 Proper Usage

Proper usage of Ponstel requires strict adherence to your doctor’s orders. Read the medication guide carefully. Ask your pharmacist if you have any queries.

Take this medicine by mouth with a full glass of water. Swallow it as a whole, do not crush, chew or break it. Take it with food if you have stomach upsets after taking it.


It is different for different patients. Dosage mentioned below is an average dose. You must follow your doctor’s instructions.

For menstrual cramps

Adults and children above 14 years of age: Take the first dose of 500 milligrams (mg), then 250 mg every 6 hours as needed.

For mild to moderate pain

Adults and children above 14 years of age: Take the first dose of 500 mg, then 250 mg every 6 hours as needed.

The dose of children below 14 years of age is determined by your doctor for any above conditions.

Missed dose 

If you miss a dose, take it as soon as you remember it. If it almost a time for your next dose skips the missed dose and continue your daily schedule. Doubling the dose is harmful.


Store it at room temperature. Keep it away from children.

4 Precautions to Take

Before using Ponstel, there are some precautions you must take. Your doctor should check your daily progress at regular visits.

He may want a blood or urine test to check for unwanted effects. This medicine may increase your risk of heart attack if you have a history of heart disease.

Inform your doctor if you notice any:

It may cause stomach ulcers or bleeding. It increases risk if you have a past history of stomach ulcers if you are a smoker, drink alcohol daily, has a poor health or you are above 60 years of age. It can cause liver diseases.

Inform your doctor if you notice any of these symptoms such as:

  • upper stomach pain
  • pale stools
  • dark urine
  • loss of appetite
  • nausea
  • unusual tiredness or weakness
  • yellow eyes or skin

Mefenamic acid can cause anaphylactic reactions.

Inform your doctor immediately if you start having:

  • rash
  • itching
  • fainting
  • palpitation
  • trouble breathing
  • swelling of hand face and mouth

Use an effective form of birth control methods as the Mefenamic acid can harm an unborn baby.

Tell your doctor or dentist that you take Mefenamic acid before you receive any medical or dental care, emergency care, or surgery.

Inform your doctor right away if you notice any edema (fluid retention/body swelling) or an unexplained weight gain. It may cause a serious skin reaction.

Inform your doctor right away if you notice any:

  • blistering
  • peeling or loosening of the skin
  • chills
  • cough
  • diarrhea
  • fever
  • itching
  • joint or muscle pain
  • red skin lesions

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Ponstel. Some people may experience none or minor side effects.

Consult with your doctor if they become problematic or frequent:

More common are:

Less common are:

  • Bleeding gums
  • Blood in vomit
  • Blurred vision
  • Burning feeling in the chest or stomach
  • Chest pain
  • Clay-colored stools
  • Cloudy urine
  • Confusion
  • Constipation
  • A cough or hoarseness
  • Dark urine
  • Difficult or labored breathing
  • Difficult, burning, or painful urination
  • Difficulty in swallowing
  • Dilated neck veins
  • Dizziness
  • Extreme fatigue
  • Fainting
  • Fast, pounding, or irregular heartbeat or pulse

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.