PrandiMet

1 What is PrandiMet?

Brand: PrandiMet

Generic: Repaglinide and Metformin

PrandiMet is used for the treatment of hyperglycemia secondary to type 2 diabetes. Type 2 diabetes is initially controlled by diet, but often drugs are needed to help your body.

Repaglinide stimulates insulin secretion from the pancreas into the blood stream. Metformin reduces the absorption of sugar, reduces the release of stored sugar from the liver, and helps your body's cells use sugar better. This drug requires a prescription.

2 What to Know Before Using

Before using PrandiMet, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in children regarding the correlation of age to the effects of repaglinide and metformin combination have not been performed while safety and efficacy have not been established.

Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of repaglinide and metformin combination. Adjustments in the dose of the elderly may be required since they are more likely to have age-related kidney problems.

Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. Infant risk is still undetermined when using this drug during breastfeeding. Discuss with your healthcare professional about the potential risks and benefits of taking this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other prescription and nonprescription drugs. Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects. Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as:

3 Proper Usage

Proper usage of PrandiMet requires strict adherence to your doctor’s orders. Take this drug exactly as directed on the label or as prescribed by your healthcare professional. Proper meal plan, regular exercise, and monitoring of blood should be done.

Take this drug within 15 minutes before a meal but may be taken up to 30 minutes before a meal. Skip your dose if you skip a meal. The dose of this drug will be variable for different patients.

The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

Adults with type 2 diabetes are initially given 500 milligrams metformin two times a day. Your healthcare professional may gradually increase your dose until your blood sugar is controlled.

Use and dose in children must be determined by your healthcare professional. Adults on metformin therapy are initially given 1-milligram repaglinide and 500 milligrams metformin combination two times a day.

Your healthcare professional may gradually increase your dose until your blood sugar is controlled. Use and dose in children must be determined by your healthcare professional.

Adults not on repaglinide and metformin therapy are initially given either the 1-milligram repaglinide and 500 milligrams metformin combination two or three times a day or 2 mg repaglinide and 500 mg metformin combination two or three times a day, as directed by your healthcare professional.

Your healthcare professional may increase your dose as needed to control your blood sugar up to a maximum of 10 mg repaglinide and 2500 mg metformin combination per day, divided into two or three doses.

Use and dose in children must be determined by your healthcare professional. The dose in adults previously treated separately with repaglinide and metformin is the same as the dose you are already taking.

Your healthcare professional may gradually increase your dose until your blood sugar is controlled. Use and dose in children must be determined by your healthcare professional.

A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

Before using PrandiMet, there are some precautions you must take. Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug. Unwanted effects can be screened using blood tests.

Alcohol intake may cause hypoglycemia. Make the necessary precautions against hypoglycemia and hyperglycemia. Wear any identification material stating that you are a diabetic taking this drug.

Check with your healthcare professional before you take any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with PrandiMet. Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool pale skin
  • cough
  • depression
  • the difficulty with swallowing
  • dizziness
  • fast heartbeat
  • headache
  • hives
  • itching or skin rash
  • increased hunger
  • nausea
  • nightmares
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • seizures
  • shakiness
  • slurred speech
  • tightness in the chest
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

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