Premarin vaginal cream is a mixture of estrogen hormones used for the treatment of changes in and around the vagina such as vaginal dryness, itching, and burning caused by low estrogen levels or menopause.
This drug can also use for sexual intercourse-related vaginal pain.
2 What to Know Before Using
Before using Premarin vaginal, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.
Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in children on the correlation of age to the effects of PremarinВ® injection have not been performed while safety and efficacy have not been established.
Studies in the elderly have not reported any geriatric-specific problems. Caution is required in giving this drug to elderly patients as they are more likely to have breast cancer, stroke, or dementia.
Fetal abnormalities have been found out in studies of animals and pregnant women. This drug is not recommended for use in women who are or may become pregnant because the risk clearly outweighs any possible benefit.
This drug may alter milk production or composition. Monitor your infant for side effects and adequate milk intake if an alternative to this medication is not prescribed. Discuss with your healthcare professional about the risks and benefits of this drug before breastfeeding.
Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.
Inform your healthcare professional if you are taking any other drugs such as Bupropion, Dasabuvir, Donepezil, Clarithromycin, Etoricoxib, Ginseng, Ketoconazole, Levothyroxine, Licorice, St John's Wort, or Tipranavir.
Inform your healthcare professional if you are taking any other prescription or non-prescription drugs. Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects.
Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.
Inform your healthcare provider for any other medical problems such as:
Proper usage of Premarin vaginal requires strict adherence to your doctor’s orders. To prevent any side effects, take this drug exactly as directed on the label or as prescribed by your healthcare professional.
Use this drug in the vagina only at bedtime. Proper hand washing with soap and water before and after using this drug is recommended. Remove cap from the tube and screw the nozzle end of the applicator to the tube.
Gently squeeze tube from the bottom to force enough amount into the barrel. Use the marked stopping points on the applicator to measure the correct dose.
Unscrew the applicator from the tube, and lie on the back with knees drawn up, and gently insert the applicator deeply into the vagina and press plunger downward to its original position.
Wash the applicator with mild soap and water. Do not use hot water. The dose of this drug will be variable for different patients.
The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.
Adults with atrophic vaginitis and kraurosis vulvae are initially advised to use 0.5 gram (g) into the vagina once a day, for 21 days, followed by 7 days without using. Use in children is not recommended.
For treatment of painful sexual intercourse in adults, 0.5 gram is used in the vagina two times a week, or in cycles. Use in children is not recommended.
A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.
Store the drug in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.
Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.
4 Precautions to Take
Before using Premarin vaginal, there are some precautions you must take. Your health care provider should closely monitor the effectiveness of this drug as well as check for unwanted effects. Unwanted effects can be detected using pelvic exam, breast exam, and mammogram.
Pregnancy is very unlikely in postmenopausal women but it is important to note that this drug has teratogenic effects. Increased risk for having blood clots, strokes, or heart attacks have been associated with this drug.
This risk may continue even after you stop using the drug and this risk is amplified if you have hypertension, high cholesterol in your blood, diabetes, or if you are overweight or smoke cigarettes.
Contact emergency medical services immediately if you experience confusion, difficulty speaking, double vision, headaches, an inability to move arms, legs or facial muscle, or an inability to speak.
Consult with your healthcare professional about the risk and benefits of this drug and if you should also use a progestin drug if you still have your uterus.
Inform your healthcare professional immediately if you have unusual vaginal bleeding. Women 65 years of age and older taking this drug may have increased risks of dementia.
Before any kind of surgery or emergency treatment, inform the medical doctor or dentist in charge that you are using this drug. This drug may also affect the results of certain medical tests.
Consult with your healthcare professional immediately if you experience a severe headache or sudden loss of vision or any other change in vision occurs while you are taking this drug. You may be referred to an ophthalmologist to have your eyes checked.
Consult with your healthcare professional before drinking grapefruit juice, or take any other prescription or nonprescription drugs, and herbal or vitamin supplements.
5 Potential Side Effects
As with many medications, there are several potential side effects associated with Premarin vaginal. Side effects may vary for each individual and prompt medical attention should be given if they occur.
Consult with your healthcare professional immediately if you experience symptoms of:
Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.
If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.
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