1 What is Prezcobix?

Brand: Prezcobix

Generic: Darunavir and Cobicistat

Prezcobix is indicated for the treatment of HIV. Prezcobix is an HIV-1 protease inhibitor, whereas cobicistat is a CYP3A inhibitor. It is important to note that this drug combination does not cure HIV nor does is prevent its spread.

It will, however, stop the virus from reproducing and delay complications caused by the condition. You can only buy this medication with a prescription and it’s sold as a tablet.

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2 What to Know Before Using

Before using Prezcobix, you must know all about the risks and complications associated with it. You also need to consider a number of factors in order to make sure that the drug combination is a good fit for you.

Inform your doctor if you have had an allergic reaction to this medication. You should also inform your healthcare provider if you have allergies to food, dyes, preservatives, animals or other medications.

Studies regarding the effects of Prezcobix on pediatric patients have not been done. So safety and efficacy have not been established.

In geriatric patients, however, studies have found that Prezcobix does not cause age-specific problems although this age group is more at risk of developing liver problems due to age. This drug combination must still be used with caution in the elderly.

Prezcobix has a pregnancy category of C, and its effects on the breastfeeding infant have not been studied adequately. Use this medication with caution.

Do not use this medicine with the following:

  • alfuzosin
  • astemizole
  • conivaptan
  • domperidone
  • dronedarone
  • eliglustat
  • ergotamine
  • fosphenytoin
  • ibrutinib
  • lovastatin
  • midazolam
  • phenytoin
  • quetiapine
  • romidepsin
  • simvastatin
  • terfenadine
  • triazolam
  • vemurafenib
  • vinflunine
  • vorapaxar

Simultaneous use of the following medicines are usually not recommended but is sometimes necessary:

  • afatinib
  • amiodarone
  • amitriptyline
  • bosentan
  • cabazitaxel
  • cilostazol
  • clozapine
  • dasabuvir
  • desipramine
  • disopyramide
  • elvitegravir
  • estradiol cypionate
  • etonogestrel
  • flecainide
  • fosamprenavir
  • haloperidol
  • lapatinib
  • macitentan
  • mifepristone
  • nevirapine
  • norelgestromin
  • ondansetron
  • palbociclib
  • perphenazine
  • prednisolone
  • rifabutin
  • saquinavir
  • tadalafil
  • toremifene
  • vilanterol
  • vinblastine
  • voriconazole
  • warfarin

Make sure you give your doctor a complete list of your medications.

If you have the following conditions, inform your doctor:

This drug combination may make these conditions worse. Also, Prezcobix should not be given to patients with the severe liver disease.

3 Proper Usage

Proper usage of Prezcobix requires strict adherence to your doctor’s orders. Do not change the dosage or timing without consulting your doctor first.

If you are low on supply, get your prescription refilled before you run out. It is important that you keep on taking this medication unless your doctor says otherwise.

Take didanosine 1 hour or 2 hours after taking Prezcobix. Adult patients usually get 800 mg, and the dose for children should be determined by their doctor.

If you miss a dose and it’s been over 12 hours, skip it and resume normal timing. Do not double dose. Keep your medications in a safe place and away from the reach of children.

4 Precautions to Take

In using Prezcobix, you must be careful and take some precautions as advised by your doctor. Go to your follow-up appointments diligently. It is important that your doctor can keep track of your progress.

You should also get regular blood and urine tests, which your doctor will order.

Watch out for signs of liver problems like:

  • tenderness in the upper stomach
  • dark urine
  • pale stools
  • loss of appetite
  • unusual weakness
  • nausea
  • yellow discoloration of the skin or eyes

If you do have them, get in touch with your doctor right away.

This medication can also affect the skin and cause:

You should also monitor your blood sugar level while taking this medication. You may also gain weight while on this medicine. Inform your doctor if you notice changes in your body shape.

Remember, however, that this medication does not cure HIV nor does it prevent its spread if you have unprotected sex. So use a latex condom when having intercourse. Do not take over-the-counter medications without consulting your doctor.

5 Potential Side Effects

Make sure you meet with your doctor in using Prezcobix to avoid unwanted potential side effects. There are several associated side effects of using Prezcobix.

If you experience the following, contact your physician right away:

The incidence of the following side effects is not known but still would need treatment:

  • abdominal pain
  • agitation
  • coma
  • confusion
  • decreased appetite
  • depression
  • dizziness
  • headache
  • fever
  • irritability
  • lethargy
  • loss of appetite
  • nausea and vomiting
  • rapid weight gain
  • seizures
  • stupor
  • lower limb swelling
  • yellow eyes or skin

However, you may not experience all of the side effects. If you start having side effects that are not listed here, get in touch with your doctor immediately.

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