1 What is Prolixin?

Brand: Prolixin

Generic: Fluphenazine

Prolixin is a drug used in the treatment of manifestations of psychotic disorders. This drug is available as a tablet containing 1 mg, 2.5 mg 10 mg or 5 mg of fluphenazine hydrochloride.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Prolixin may interact with medications such as:

  • Anticholinergics such as:
    • Atropine
  • Dopamine agonists such as:
    • Cabergoline
    • or Pergolide
  • Guanadrel
  • Guanethidine
  • Lithium
  • Sibutramine
  • Isoniazid
  • Theophylline
  • Bupropion
  • Tramadol
  • Antihistamines that cause drowsiness such as:
    • Diphenhydramine
  • Anti-anxiety drugs such as:
    • Diazepam
  • Anti-seizure drugs such as:
    • Carbamazepine
  • Medicine for sleep such as:
    • Zolpidem
  • Muscle relaxants
  • Narcotic pain relievers such as:
    • Codeine
  • Other psychiatric medicines such as:
  • Tranquilizers

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to fluphenazine or to other phenothiazines
  • Brain damage
  • Severe nervous system problems
  • Blood problems
  • Liver problems
  • Breast cancer
  • Eye problems
  • Heart problems
  • Kidney problems
  • Certain types of tumors such as:
  • Seizures
  • Exposure to phosphorus insecticides
  • Chronic/ long-term breathing problems such as:
  • Low blood calcium
  • Enlarged prostate
  • Drug or alcohol dependency
  • Reye's syndrome
  • Other nervous system problems
  • Dehydration
  • Pregnancy or lactation

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