1 What is Synalgos-DC?

Brand: Synalgos-DC

Generic: Aspirin, Caffeine, and Dihydrocodeine

Synalgos-DC is used to relieve moderate to moderately severe pain. Aspirin is also known as an anti-inflammatory analgesic. It is a salicylate that is used to relieve pain and reduce fever or inflammation.

Caffeine is a central nervous system stimulant that is used with pain relievers to boost their effect. It can be used in treating migraine headaches. Dihydrocodeine is a narcotic analgesic that acts on the central nervous system to relieve pain.

It can cause mental or physical dependence when it was used for a long time or in large doses. This product is available in capsules.

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2 What to Know Before Using

Before using Synalgos-DC, you must know all about the risks and complications associated with it. Safety and effectiveness of Synalgos-DC have not been established in children.

This medicine should not be used to relieve pain after tonsillectomy and/or adenoidectomy in any children. Severe breathing problems and deaths have been reported in some children who received codeine after the said surgeries.

Although this medicine has not demonstrated geriatric-specific problems, older patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving aspirin, caffeine, and dihydrocodeine combination.

There are no adequate studies whether Synalgos-DC can pass through breast milk or if it could cause harmful effects to the infant. Discuss with your doctor if you are breastfeeding a baby.

Taking this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dichlorphenamide
  • Influenza Virus Vaccine, Live
  • Ketorolac
  • Naltrexone
  • Riociguat

Taking any of the following medicines with Synalgos-DC usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or frequency of one or both of your medicines.

  • Abciximab
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Anagrelide
  • Anisindione
  • Apixaban
  • Ardeparin
  • Argatroban
  • Beta Glucan
  • Bivalirudin
  • Bromazepam
  • Buprenorphine
  • Butorphanol
  • Carbinoxamine
  • Certoparin
  • Cilostazol
  • Citalopram
  • Clomipramine
  • Clopidogrel
  • Cyclosporine
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desipramine
  • Desirudin
  • Desvenlafaxine
  • Dezocine
  • Dibenzepin
  • Dicumarol
  • Dipyridamole
  • Dipyrone
  • Donepezil
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Eptifibatide
  • Erlotinib
  • Escitalopram
  • Fentanyl
  • Feverfew
  • Flibanserin
  • Flufenamic Acid
  • Fluoxetine
  • Fluvoxamine
  • Fondaparinux
  • Ginkgo
  • Gossypol
  • Heparin
  • Hydrocodone
  • Imipramine
  • Ketoprofen
  • Lepirudin
  • Levomilnacipran
  • Lofepramine
  • Meclizine
  • Mefenamic Acid
  • Melitracen
  • Meptazinol
  • Methadone
  • Methotrexate
  • Milnacipran
  • Morphine
  • Morphine Sulfate Liposome
  • Nadroparin
  • Nalbuphine
  • Naproxen
  • Nefazodone
  • Nortriptyline
  • Opipramol
  • Oxycodone
  • Oxymorphone
  • Parnaparin
  • Paroxetine
  • Peginterferon Alfa-2b
  • Pemetrexed
  • Pentazocine
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Phenindione
  • Phenprocoumon
  • Piroxicam
  • Pixantrone
  • Pralatrexate
  • Prasugrel
  • Propyphenazone
  • Protein C
  • Protriptyline
  • Reteplase, Recombinant
  • Reviparin
  • Rivaroxaban
  • Sertraline
  • Sildenafil
  • Sulindac
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Tianeptine
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Treprostinil
  • Trimipramine
  • Varicella Virus Vaccine
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin

Taking this medicine with any of the following medications may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Alprenolol
  • Amiloride
  • Arotinolol
  • Atenolol
  • Azosemide
  • Befunolol
  • Bemetizide
  • Bendroflumethiazide
  • Benzthiazide
  • Betamethasone
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bopindolol
  • Bucindolol
  • Bumetanide
  • Bupranolol
  • Buthiazide
  • Canrenoate
  • Captopril
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Celiprolol
  • Chlorothiazide
  • Chlorthalidone
  • Clopamide
  • Cortisone
  • Cyclopenthiazide
  • Delapril
  • Dexamethasone
  • Dilevalol
  • Enalaprilat
  • Enalapril Maleate
  • Esmolol
  • Ethacrynic Acid
  • Furosemide
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Imidapril
  • Indapamide
  • Labetalol
  • Landiolol
  • Levobunolol
  • Lisinopril
  • Mepindolol
  • Methyclothiazide
  • Methylprednisolone
  • Metipranolol
  • Metolazone
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Nipradilol
  • Nitroglycerin
  • Oxprenolol
  • Paramethasone
  • Penbutolol
  • Phenylbutazone
  • Pindolol
  • Piretanide
  • Polythiazide
  • Prednisolone
  • Prednisone
  • Probenecid
  • Propranolol
  • Rofecoxib
  • Sotalol
  • Spironolactone
  • Streptokinase
  • Talinolol
  • Tamarind
  • Temocapril
  • Tenecteplase
  • Tertatolol
  • Timolol
  • Torsemide
  • Triamcinolone
  • Triamterene
  • Trichlormethiazide
  • Valproic Acid
  • Xipamide

Using Synalgos-DC with tobacco is usually not recommended, but may be unavoidable in some cases. Also, using this medication with Ethanol may cause an increased risk of certain side effects but may be unavoidable in some cases.

If used together, your physician may change the dose or how often you use this medicine. Special instructions may also be given. Some medical conditions can interact with this medication.

Tell your doctor if you have any of the following conditions:

  • Alcohol abuse
  • Breathing problems
  • Drug dependence, especially with narcotics
  • Weakened physical condition
  • Blood clotting problems
  • Peptic ulcer disease
  • Surgery (eg, nasopharyngeal tonsils, tonsils)—Should not be used in patients with this condition.

3 Proper Usage

To use Synalgos-DC properly, you must follow all instructions given by your doctor. Prolonged use of this medication may become habit-forming and can cause mental or physical dependence.

Oral dosage form for moderate to moderately severe pain:

  • Adults—Two capsules every 4 hours as needed.
  • Children—Use and dose must be determined by your doctor.

Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of reach of children. Do not keep expired medications.

4 Precautions to Take

Before using Synalgos-DC, there are some precautions you must take. Check with your doctor on regular visits to monitor your progress with the medication.

Synalgos-DC will add to the effects of alcohol and other CNS depressants. Check with your doctor before taking CNS depressants while you are using this medicine.

If you feel that the medicine is not working as well, do not use beyond your prescribed dose. Call your doctor for instructions.

This medicine can cause dizziness or drowsiness. Avoid driving, operating machinery, or any other risky activities when you take this medication.

Prolonged use of narcotics can cause severe constipation. Drink plenty of fluids and eat high-fiber foods to prevent this problem.

Call for help immediately if think you or someone else may have taken an overdose of this medicine. Signs of an overdose include convulsions, breathing problems, nausea or vomiting, pain in the upper stomach, pale or blue lips/fingernails/skin, yellow eyes or skin, pinpoint pupils of the eyes, or sleeping difficulty.

Tell your doctor if you are taking any other medication as drug interaction may occur when two or more drugs are being taken at the same time.

Codeine is converted to morphine in the body. Individuals who are called ultra-rapid metabolizers of codeine can convert codeine to morphine faster than the others. They may experience overdose symptoms such as extreme sleepiness, confusion, or shallow breathing. Children may be especially sensitive to this effect.

If a breastfeeding mother is an ultra-rapid metabolizer of codeine, it could lead to a morphine overdose in the infant and cause very dangerous side effects.

For breastfeeding mothers taking this medicine:

  • Discuss with your doctor the risk and the benefits of codeine as well as the effects of this medication to your baby.
  • If you become extremely tired and have difficulty caring for your baby, call your doctor right away. Your baby should generally nurse every 2 to 3 hours and should not sleep more than 4 hours at a time.
  • Go to the hospital emergency room immediately if your baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, troubled breathing, or limpness as these may be symptoms of an overdose.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Synalgos-DC. Check with your doctor as soon as possible if you experience lightheadedness.

Call for help immediately if any of the following symptoms of overdose occur:

  • Confusion
  • Difficult or troubled breathing
  • Extreme sleepiness
  • Irregular, fast or slow, or shallow breathing
  • Pale or blue lips, fingernails, or skin
  • Shortness of breath

Less serious side effects of Synalgos-DC:

  • Difficulty having a bowel movement
  • Dizziness
  • Drowsiness
  • Itching skin
  • Nausea
  • Relaxed and calm
  • Sleepiness
  • Vomiting

Not all side effects are listed above. If you notice any other effects, check with your healthcare professional.