1 What is Synarel?

Brand: Synarel

Generic: Nafarelin

A man-made hormone, Synarel is similar to the hormone released from the brain’s hypothalamus gland.

2 What to Know Before Using

Before using Synarel, you must know all about the risks and complications associated with it.

Before using this drug, you and your doctor must consider the following:

Allergies: If you have any unusual reaction to any medicine, be sure to tell your doctor about it. Additionally, disclose other types of allergies - foods, preservatives, animals, or dyes, if there are any. Read the package ingredients carefully and make sure you are not allergic to any of its ingredients.

Pediatric: Studies done in children show no pediatric-specific problems limiting the usefulness of the medicine in children. However, it is not sure if children using the nasal spray at the time of puberty may cause changes in their future ability to have children. It is important to discuss with your doctor the risks and benefits of using this drug in children.

Geriatric: No available information on the relationship of geriatric age bracket to the effects of this drug.

Pregnancy: The use of this drug will cause positive side effects to the fetus, including abnormalities with the development. Do not use this drug if you are pregnant or have a possibility to get pregnant since the risk positively outweighs any benefit.

Breastfeeding: Although there are no adequate studies in lactating mothers that determine potential risk in an infant when breastfeeding, the benefits should be weighed against the risks before taking this medication.

Drug Interactions: Some drugs have adverse effects when used together. Make sure to inform your doctor about other drugs you are taking, so that alterations and precautions will be made if necessary. Before using nafarelin nasal spray, talk to your doctor about possible interactions if you are taking other medications.

It is also important to inform your doctor if you are smoking tobacco or drinking alcohol since these may interact with the drug’s effectiveness. Inform your doctor about any drug you are using, prescription or nonprescription, as well as vitamin and herbal supplement.

Other Medical Problems: How you use this medicine may be affected if you have other medical problems, Inform your doctor about any other health conditions. Do not use this drug if you have unusual vaginal bleeding. Use with caution if you smoke cigarettes, have alcohol abuse, history of osteoporosis, rhinitis, ovarian cycts, or pityuitary gland problem.

3 Proper Usage

To use Synarel properly, you must follow all instructions given by your doctor. Do not increase the dosage or use it more often than prescribed. Doing so only increases the absorbed amount of medicine, hence the higher chance of unwanted side effects.

Dosing: The following dosing information includes only the average prescribed dose for this medicine. Follow your doctor’s orders even if it is different from what it is written here or on the insert.

In treating central precocious puberty in children, two sprays in each nostril, to be applied twice a day, in the morning and at night. Some patients may require more doses, and your doctor may increase your dose to up to 9 sprays a day.

In treating endometriosis in adults, the usual dose is one spray in one nostril in the morning plus one spray in the other nostril at night. Treatment usually lasts for 6 months, or until advised by the doctor. Start treatment on the 2nd, 3rd, or 4th days of your menstrual period.

Missed dose: Take the missed dose as soon as possible. In case it is almost time for the next dose, skip the missed one and follow your regular dosing schedule. Never take double doses.

Storage: Keep the medicine in an airtight container at normal room temperature. Keep it away from direct light, heat, and moisture. Do not let it freeze. Keep the medicine out of children’s reach. Throw the spray bottle away after using 60 sprays, so it is ideal to keep track of your usage.

4 Precautions to Take

Before using Synarel, there are some precautions you must take. Regular visits to the doctor are important to check your progress and make sure Synarel is working properly. You may need to get your blood checked to see if there are any unwanted side effects.

For female patients, you must not take this drug if you are pregnant or have a possibility of getting pregnant. Taking this medicine during pregnancy is harmful to the unborn baby. Inform your doctor right away if you think you have become pregnant while using this medicine.

For children using this drug for central precocious puberty, the medicine can cause a temporary increase in levels of some hormones in the blood.

When this occurs, signs of puberty may be more noticeable, such as breast enlargement and light vaginal bleeding in girls. If the symptoms do not go away within 4 weeks, or if they aggravate, consult your doctor.

For women with endometriosis using this spray, the symptoms may get worse for the first few days of treatment. Do not stop taking this medicine as this is just normal. You may talk with your doctor about your concerns.

While using this drug, you may experience irregular periods or no menstruation at all. Consult your doctor if regular menstruation does not take place within 2-3 months after stopping the use of this drug.

While using the nasal spray, do not use birth control that contains hormones. IUD, condoms, cervical cap with spermicide or diaphragm are recommended.

Do not take any other drugs unless prescribed by your doctor. This includes nonprescription or prescription drugs, vitamins, and herbal supplements.

5 Potential Side Effects

You may or may not feel side effects from using Synarel. If any side effect occurs, however, you may need to contact your doctor.

While some of the side effects may not require medical attention, some might be too serious that you may need emergency assistance.

Most of the time, the side effects go away as the body gets used to the medicine. Ask your doctor what you can do to manage the drug’s side effects.