1 What is Synercid?

Brand: Synercid

Generic: Quinupristin and Dalfopristin

Synercid is antibiotic used in the treatment of bacterial infections of the skin and the blood.

Its use is reserved for severe bacterial infections that do not respond to other medicines.

You can get the injection of this medicine only after your doctor prescribes it for you. It is available in a powder for solution form.

2 What to Know Before Using

Before using Synercid, you must know all about the risks and complications associated with it. Together with your doctor, you can decide whether the medication will do you more goods than the harms.

Here are some factors to be considered before deciding to use this medicine:

Allergies: Inform your doctor about the allergies you have, such as to this medication, other medications, or to foods, dyes, or preservatives.

Pediatric: Safety and efficacy of this medicine in children below 16 years have not been well documented.

Geriatric: It is generally safe for use in elderly.

Pregnancy: It falls under category B for all trimesters meaning that this medicine is generally safe for use in pregnancy.

Breastfeeding: It may be used in a nursing mother after assessing risks and benefits of the use.

Drug Interactions: Taking two medicines together can be harmful due to possible interactions. In other cases, even if there is a possible interaction between two medicines your doctor may advise you to take them together after adjusting the dose or issuing precautions.

Though usually not recommended, your doctor may decide, after adjusting dose or frequency of one or both medicines, to use this medicine with any of the following medicines:

  • Astemizole
  • Atorvastatin
  • Cerivastatin
  • Fluvastatin
  • Haloperidol
  • Lovastatin
  • Pravastatin
  • Simvastatin
  • Tacrolimus
  • Vinblastine
  • Vincristine
  • Vinorelbine

Rarely and only when absolutely needed, this medicine may be used with the following medicines even if using them together may put you at risk of certain side effects.

In such cases, you may have to take the adjusted dose or change the frequency of intake.

  • Carbamazepine
  • Cyclosporine
  • Delavirdine
  • Diazepam
  • Diltiazem
  • Disopyramide
  • Docetaxel
  • Felodipine
  • Indinavir
  • Isradipine
  • Lacidipine
  • Lidocaine
  • Manidipine
  • Methylprednisolone
  • Midazolam
  • Nevirapine
  • Nicardipine
  • Nifedipine
  • Nilvadipine
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Paclitaxel
  • Quinidine
  • Ritonavir
  • Verapamil

Other Interactions: Taking your medicine together with certain foods or items such as alcohol or tobacco may cause undesirable interactions. Talk to your doctor to know if using this medicine with food, alcohol, or tobacco is safe.

Medical Problems: Certain medical conditions might influence the effects (both positive and adverse) and action of this medicine.

Inform your doctor if you have the following conditions if any:

3 Proper Usage

Proper usage of Synercid requires strict adherence to your doctor’s orders.

Something for you to know:

  • A nurse will inject this medicine into your vein by using a needle. It will take about 1hour for all of the medicine to pass through your veins. So, be patient.
  • A full course of antibiotic is necessary to treat your condition.
  • This medicine shows better results when used on a regular schedule.

4 Precautions to Take

Before using Synercid, there are some precautions you must take. Your progress should be regularly monitored to determine if you are responding to the treatment.

You may also need blood tests to detect any undesirable effects. Remember:

  • Seek medical help if you do not seem to respond to the treatment or your symptoms worsen.
  • You may have severe diarrhea during and more than 2 months after completion of the treatment. In such case, consult your doctor before using any medicine to control diarrhea.
  • Consult your doctor before using any prescription or nonprescription medicines and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Synercid.

Consult your doctor immediately if you experience any of the following side effects:

More common:

  • Red, swollen, or painful injection site

Less common: 

  • Altered skin color
  • oSkin irritations
  • Pain in joint or muscle
  • Swollen foot or leg


  • Restlessness
  • Anxiety
  • Pain in back, chest, leg, bone or stomach
  • Chest pain radiating to the left arm, neck, or shoulder
  • Black, tar-like stools
  • Bleeding from gums or nose
  • Swollen face or limbs
  • Bloody urine or stools
  • Bluish lips, fingernails, or skin
  • Vision difficulty
  • Numbness or tingling sensation in the hands, arms, feet, or legs
  • Fever and chills
  • Confusion
  • Seizures
  • A cough or hoarseness
  • Pale urine
  • Decreased urine volume
  • Difficulty breathing, swallowing, speaking or urinating
  • Dizziness
  • Feeling dizzy when changing position
  • Rapid irregular heartbeats
  • Generalized body swelling
  • Clay-colored stools
  • Incontinence
  • Decreased appetite
  • Missing pulse
  • Nausea or vomiting
  • Abnormal bleeding
  • Puffed eyelids or around the eyes, face, lips, or tongue
  • Rapid weight gain or loss
  • A severe or a sudden headache
  • Body tremors
  • Temporary loss of vision
  • Vomiting blood
  • Sudden and severe wheezing
  • Yellow eyes or skin

Incidence not known:

  • Welts on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Mild and non-serious side effects usually go away on their own without requiring medical intervention. You may also ask your doctor to learn more about how you may prevent or reduce the side effects.

Talk to your doctor if the side effects persist or worry you, including:


  • Upset stomach
  • Pain or swelling in the joint
  • Burping
  • Sweating
  • Abnormally light skin
  • Leg cramps
  • Hives
  • Sleep problems
  • Inflamed mouth
  • Abnormal vaginal discharge

The side effects of the medicine are not limited to the ones listed above. Call your doctor immediately if you experience any side effects that are uncommon or worry you. To report side effects to the FDA, contact at 1-800-FDA-1088.