1 What is Totect?

Brand: Totect, Zinecard

Generic: Dexrazoxane

Totect is a cardioprotective agent used for the prevention or reduction of the toxic effect to your heart that is caused by certain anti-cancer drugs.

This drug is also used to treat tissue damage caused by the leakage of certain anti-cancer drugs. This drug requires a prescription.

2 What to Know Before Using

Before using Totect, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in regarding the relationship of age to the effects of dexrazoxane have not been performed while safety and efficacy have not been established.

Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of dexrazoxane. Adjustments in the elderly may be required since they are more likely to have age-related kidney problems.

Risks to the fetus have reported in studies of pregnant women and animals but these may be outweighed by the benefits of therapy in a life threatening situation or a serious disease.

Infant risk is still undetermined when using this drug during breastfeeding. Discuss with your healthcare professional about the potential risks and benefits of taking this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as Doxorubicin, or Doxorubicin Hydrochloride Liposome. Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. Inform your healthcare provider for any other medical problems such as Blood disorder, a bleeding problem, or Kidney disease.

3 Proper Usage

Proper usage of Totect requires strict adherence to your doctor’s orders. A trained healthcare professional will be only to give you this drug.

This drug is administered intravenously through a needle placed into one of your veins. The dose of this drug will be variable for different patients.

The directions on the label or the prescription by your healthcare professional should be followed. The dosage of this drug you take depends on the medical problem for which you are using this drug.

4 Precautions to Take

Before using Totect, there are some precautions you must take. This drug has teratogenic potential which can harm your unborn baby.

Inform your healthcare professional immediately if you think you have become pregnant while using this drug. This drug can cause leukopenia and thrombocytopenia which can increase the risk of acquiring an infection or bleeding.

Check with your healthcare professional immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Check with your healthcare professional immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in urine or stools, or pinpoint red spots on your skin.

Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical health care professional, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical health care professional before having any dental work done.

Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.

Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Situations, where bruising or injury could occur, should be avoided.

5 Potential Side Effects

Make sure you meet with your doctor in using Totect to avoid unwanted potential side effects.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • bluish color
  • changes in skin color
  • chest pain
  • cold hands and feet
  • a cough or hoarseness
  • difficult or labored breathing
  • fever or chills
  • lower back or side pain
  • pain, redness or swelling in arm or leg
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • sneezing
  • a sore throat
  • swelling of hands, ankles, feet or lower legs
  • tenderness
  • tightness in the chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
  • black, tarry stools
  • chest discomfort
  • fast, irregular or pounding heartbeat
  • pain at place of injection
  • ulcers, sores or white spots in the mouth

Some side effects may occur that usually do not need medical attention. As your body adjusts to the drug, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

6 Related Clinical Trials