1 What is Trexall?

Brand: Trexall

Generic: Methotrexate

Trexall is a drug used in the treatment of cancers such as gynecologic cancers, breast cancer, head and neck cancer, lymphoma, leukemia, and lung cancer. It is also used to treat psoriasis and rheumatoid arthritis.

You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be injected by a health care professional. Your dosage is based on your medical condition and the way you will respond to treatment.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.

Trexall may interact with medications such as:

  • Acitretin
  • Asparaginase
  • Digoxin
  • Leflunomide
  • Live vaccines
  • Natalizumab
  • Other cancer treatments potentially toxic to the kidney such as cisplatin
  • Other drugs potentially toxic to the liver such as azathioprine, sulfasalazine or retinoids such as isotretinoin
  • Penicillins
  • Phenytoin
  • Probenecid
  • Procarbazine
  • Pyrimethamine
  • Sulfa medications
  • Theophylline.
  • Proton pumps inhibitors-PPIs such as esomeprazole, omeprazole or pantoprazole
  • Certain antibiotics such as chloramphenicol, sulfa or tetracyclines

Side Effects: There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling

Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to methotrexate
  • Liver disease
  • Severe kidney disease
  • Severe lung diseases such as pulmonary fibrosis
  • Alcohol use
  • Suppressed immune system
  • Blood cell or bone marrow disorders
  • Gastrointestinal problems
  • Kidney disease
  • Any active infection
  • Folic acid deficiency
  • Pregnancy or lactation