1 What is Tybost?

Brand: Tybost

Generic: Cobicistat

Tybost is a pharmacokinetic enhancer used to amplify the effects of atazanavir or darunavir for the treatment of human immunodeficiency virus (HIV) infection which causes acquired immune deficiency syndrome (AIDS). This drug requires a prescription.

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2 What to Know Before Using

Before using Tybost, you must know all about the risks and complications associated with it. Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. 

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications. Studies in children determining the correlation of age to the effects of cobicistat have not been performed while safety and efficacy have not been established.

There are no reports of geriatric-specific problems when taking this drug. Studies suggest that this drug has no indication of a teratogenic effect. 

Studies in women have not determined any infant risk when taking this drug during breastfeeding. Discuss with your healthcare professional the possible risks and benefits before taking this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects. 

Inform your healthcare professional if you are taking any other drugs such as:

  • Alfuzosin
  • Carbamazepine
  • Cisapride
  • Colchicine
  • Conivaptan
  • Crizotinib
  • Dabrafenib
  • Dihydroergotamine
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Eliglustat
  • Eplerenone
  • Ergonovine
  • Ergotamine
  • Eszopiclone
  • Fentanyl
  • Fosphenytoin
  • Ibrutinib
  • Isavuconazonium Sulfate
  • Ivabradine
  • Lomitapide
  • Lovastatin
  • Lurasidone
  • Maraviroc
  • Methylergonovine
  • Midazolam
  • Naloxegol
  • Pazopanib
  • Phenobarbital
  • Phenytoin
  • Pimozide
  • Primidone
  • Quetiapine
  • Ranolazine
  • Rifampin
  • Riociguat
  • Romidepsin
  • Sildenafil
  • Silodosin
  • Simvastatin
  • St John's Wort
  • Suvorexant
  • Tolvaptan
  • Triazolam
  • Vemurafenib
  • Vinflunine
  • Vorapaxar
  • Ado-Trastuzumab
  • Emtansine
  • Afatinib
  • Alprazolam
  • Amiodarone
  • Amprenavir
  • Apixaban
  • Aprepitant
  • Aripiprazole
  • Avanafil
  • Bedaquiline
  • Boceprevir
  • Bosentan
  • Bosutinib
  • Bromocriptine
  • Budesonide
  • Cabazitaxel
  • Cabozantinib
  • Cariprazine
  • Ceritinib
  • Cilostazol
  • Clarithromycin
  • Clozapine
  • Cobimetinib
  • Cyclophosphamide
  • Cyclosporine
  • Dasatinib
  • Delamanid
  • Delavirdine
  • Dexamethasone
  • Diazepam
  • Digoxin
  • Disopyramide
  • Docetaxel
  • Domperidone
  • Donepezil
  • Eletriptan
  • Erlotinib
  • Erythromycin
  • Etravirine
  • Everolimus
  • Flecainide
  • Fluoxetine
  • Fluticasone
  • Fosamprenavir
  • Haloperidol
  • Idelalisib
  • Ifosfamide
  • Iloperidone
  • Imatinib
  • Irinotecan
  • Irinotecan Liposome
  • Itraconazole
  • Ketoconazole
  • Lapatinib
  • Levomilnacipran
  • Lidocaine
  • Lopinavir
  • Macitentan
  • Mexiletine
  • Mifepristone
  • Morphine
  • Morphine Sulfate Liposome
  • Nevirapine
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Olaparib
  • Osimertinib
  • Oxcarbazepine
  • Oxycodone
  • Palbociclib
  • Panobinostat
  • Paritaprevir
  • Piperaquine
  • Pixantrone
  • Ponatinib
  • Propafenone
  • Quinidine
  • Regorafenib
  • Retapamulin
  • Rifabutin
  • Rifapentine
  • Ritonavir
  • Rivaroxaban
  • Rosuvastatin
  • Ruxolitinib
  • Salmeterol
  • Saquinavir
  • Saxagliptin
  • Simeprevir
  • Sirolimus
  • Sunitinib
  • Tacrolimus
  • Tadalafil
  • Tamoxifen
  • Tamsulosin
  • Telithromycin
  • Temsirolimus
  • Ticagrelor
  • Tipranavir
  • Topotecan
  • Toremifene
  • Trabectedin
  • Tramadol
  • Trazodone
  • Vardenafil
  • Vilanterol
  • Vilazodone
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Voriconazole
  • Warfarin
  • Atazanavir
  • Darunavir
  • Indinavir
  • Nelfinavir

Inform your healthcare professional if you are taking any other prescription or non-prescription drugs. Intake of specific food or using alcohol or tobacco with magnesium is associated with an increased risk of certain side effects. 

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco. Inform your healthcare provider for any other medical problems such as kidney disease.

3 Proper Usage

Proper usage of Tybost requires strict adherence to your doctor’s orders. To prevent any side effects, take this drug exactly as directed on the label or as prescribed by your healthcare professional. Take this drug with food. 

Consult with your healthcare professional before you change your dose or if you want to stop taking this drug. Always reserve a decent amount of this drug for future use. Take this drug at least 2 hours before or after cobicistat with atazanavir if you are also taking an antacid containing aluminum or magnesium. 

Seek advice from your healthcare professional before taking any other drugs for your stomach or heartburn. The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed. 

The dosage of this drug you take depends on the medical problem for which you are using this drug.  For enhancement of atazanavir or darunavir in adults are prescribed 150 milligrams once a day, taken with atazanavir 300 mg once a day or darunavir 800 mg once a day. 

Use and dose in children must be determined by your healthcare professional. A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose. 

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.  

Do not use this drug if the seal on the bottle is broken or missing. Keep the bottle tightly closed. Keep the drug in the original bottle that you were given at the pharmacy.

4 Precautions to Take

Before using Tybost, there are some precautions you must take. Your health care provider should closely monitor the effectiveness of this drug as well as check for unwanted effects. Unwanted effects may be screened using blood and urine tests. 

To prevent unwanted side effects, refrain from using this drug together with atazanavir or darunavir if you are also using any of the following: 

  • alfuzosin (UroxatralВ®)
  • carbamazepine (TegretolВ®)
  • cisapride (PropulsidВ®)
  • dronedarone (MultaqВ®)
  • indinavir (CrixivanВ®)
  • irinotecan (CamptosarВ®)
  • lovastatin (AltoprevВ®, MevacorВ®)
  • midazolam (VersedВ®)
  • nevirapine (ViramuneВ®)
  • phenobarbital (LuminalВ®)
  • phenytoin (DilantinВ®)
  • pimozide (OrapВ®)
  • rifampin (RifadinВ®)
  • sildenafil (RevatioВ®)
  • simvastatin (SimcorВ®, ZocorВ®)
  • St John's wort, triazolam (HalcionВ®)
  • ergot medicines (dihydroergotamine, ergotamine, methylergonovine, CafergotВ®, MigranalВ®)

Kidney problems have been associated when taking this drug together with tenofovir DF. Inform your healthcare professional immediately if you have bloody urine, decreased frequency or amount of urine, increased thirst, loss of appetite, lower back or side pain, nausea, vomiting, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, or weight gain. 

Practice safe sex and avoid sharing needles with anyone as this drug does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contaminated blood.  

Consult with your healthcare professional before taking any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Tybost. Side effects may vary for each individual and prompt medical attention should be given if they occur. 

Inform you healthcare provider immediately if you experience any unusual symptoms such as: 

  • abdominal or stomach pain
  • bloody urine
  • chills clay-colored stools
  • dark urine
  • decreased frequency or amount of urine
  • dizziness
  • fast heartbeat
  • fever
  • headache
  • hives or welts
  • itching, or rash hoarseness
  • increased thirst
  • irritation
  • joint pain
  • stiffness, or swelling
  • loss of appetite
  • lower back or side pain
  • nausea and vomiting
  • pain in the groin or genitals
  • redness of the skin
  • sharp back pain just below the ribs
  • swelling of the eyelids, face, lips, hands, lower legs, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • weight gain
  • yellow eyes or skin
  • dark-colored urine
  • muscle cramps or spasms
  • muscle pain or stiffness

Some side effects may occur that usually do not need medical attention. As your body adjusts to the drug, these side effects may eventually disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects. 

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.