1 Phosenamine

Brand: Phosenamine, Phosphasal, Prosed/DS, Uribel, Uro Blue, Ustell, Uta, UTICAP, Utira, Utira C, Urelle, Darpaz, Hyophen

Generic: Hyoscyamine, Methenamine, Methylene Blue and Phenyl Salicylate


2 What is Uribel?

Uribel is medication that is used to get rid of distress, recurring urge to urinate and spasms experienced in the urinary tract by an infection or medical process. Methenamine is a bacterial inhibitor since it prevents bacterial growth. Methylene blue is both antiseptic and associated with drugs known as monoamine oxidase inhibitors (MAO inhibitors). Both of these prevent or stop bacterial growth in urine. Salicylate, with a similar action as aspirin, is a pain reliever. Uribel contains active ingredients, such as sodium sulphate and benzoic acid, which aid the action of methenamine, by making urine acidic. Hyoscyamine regulate spasms frequency by relaxing muscles lining the urinary tract.

If you have a bacterial infection, use prescribed antibiotics but never use Uribel to treat urinary tract infection. Ask the doctor for more information on the uses of Uribel.

Since children under six years are more prone to develop side effects, they should not be medicated with Uribel.

3 Uribel uses

Follow your doctor’s instructions on use. It is said to take the medication four times a day with plenty of water. Do not lie down within the first ten minutes of taking Uribel. Drink plenty of water during the day unless informed by the doctor. If after taking the drug you notice that you developed an stomach upset, you should take the drug alongside some food. Uribel is prescribed for patients with severe symptoms and extreme pain associated with urinary tract infections. Since uribel is not an antibiotic, it should and cannot be used to treat urinary tract infections but only the pain and symptoms resulting from the infection.

Uribel contains methenamine and methylene blue, its main active ingredients, which are antibiotics and antiseptics by nature. These two ingredients can prevent invasions of bacteria and growth in urine, thus minimizing the risk of developing any urinary tract infections. Salicylate is a pain reliever and can ease some of the discomfort, since it functions in the same manner as aspirin. Uribel also has traces of sodium phosphate and benzoic acid which cause urine to have a lower pH, improving the actions of methenamine. All those other ingredients put together give Uribel its pain relieving and antibiotic abilities.

Age, symptoms and nature of the ailment are considered before determining a safe and effective dose of Uribel. It is taken with plenty of water and if there is any pain after taking it, next time it is advised you take it with food. The frequency of the dose prescribed is usually four times a day, but it can vary depending on the underlying symptoms. Improvements usually take about two to three days to be noticed. If you feel pain after taking the drug, consult your doctor to find the best medication for you. If you take Uribel after some time and you do not get any positive feedback, it is important to consult with your doctor so that you can find the best medication for you. Pain when you urinate or any itchy feeling should be reported to the doctor to examine if you have developed any complications.

4 Uribel side effects

Although this drug is prescribed after extensively weighing the pros and cons, some symptoms may be a cause for alarm. These may include the following:

If these symptoms persist, seek medical attention. Drink plenty of fluids or chew sugar-free gums or any other saliva substitute to relieve your mouth of dryness. Uribel can cause urine to turn blue-green, but this is not harmful and will end by itself after medication has stopped. This medication does not have a lot of side effects for a majority of people who take it, but if they are severe ensure you visit a doctor.

Such serious side effects include:

  • Hot and dried up skin
  • Less production of sweat
  • Pain in the eyes
  • Straining when eliminating urine
  • Signs of developing kidney complications
  • Extreme bleeding and easy bruising
  • Premonitions of getting kidney complications
  • Abnormal stool and vomit
  • Rarely does it cause high blood pressure
  • Irregular heart beats
  • Stiff neck
  • Headache
  • Dilation of pupils and unstable focus
  • Extreme sensitivity to light
  • Cold and damp skin
  • Loss of coordination
  • Drowsiness
  • Uncontrolled muscle contractions
  • Perceptions of things that do not exist or wandering off of the mind
  • Obstructed breathing and increased difficulty in breathing

In extreme cases, serotonin syndrome or toxicity occurs. This condition is worsened if you take more drugs causing it. Seek medical attention to get a substitute drug with mild side effects. Uribel side effects are very rare and if you notice any of the above or any unexplained symptoms, seek medical attention immediately.

5 Uribel overdose

Some interventions will be done to help you relieve some of the complications created by Uribel overdose. Emesis or gastric lavage may occur, and this is whereby slow physostigmine is given through the vein in doses of 1-4 milligrams and 0.5-1 milligrams in children to alleviate antimuscarinic symptoms. The doctor will find the best intervals at which this drug is given.

Small doses of diazepam will be given to control hyperactivity and seizures. Giving artificial respiration with oxygen may be needed for suppressed breathing. Also, enough fluids may be given to maintain the body’s water content.

Symptoms are treated as needed.

If an overdose is suspected, contact your local poison centers or any emergency number hotline.

6 Precautions to take prior to using Uribel

Before you begin taking this drug, make sure you inform the doctor of medications you are not compatible with, such as aspirin or ibuprofen, or if you suspect that you may develop allergic reactions after taking this drug. This drug also contains inactive ingredients which have a potential of causing severe symptoms. Talk to your pharmacist to find out more about them.

Before being medicated with this drug, tell your doctor if you developed any severe illness in the past such as kidney problems, difficulty in expelling urine, upset stomach, heart complications, glaucoma or any other underlying problems. Tell the doctor also if you have any chronic illness, allergy or increased sensitivity to the drug. If you are on a medication that is not compatible when taken with Uribel, be sure to seek the doctor’s consent before starting to undertake any medication.

This drug may cause you to feel dizzy and cause some effects on your vision, and it is not recommend that you use any machinery or operate any vehicles when taking this pill, since you are very vulnerable to cause injury to yourself or the people around you. This is due to the side effects that may come with using the Uribel drug.

Also, minimize on the use of alcohol and tobacco since such products may cause an internal stomach hemorrhage.

This medicine can cause you to produce less sweat than normal, or get a heat stroke. Avoid activities that may cause you to produce more body heat such as taking a bath in hot water, or taking part in strenuous activities. If you overheat, soak in cold water until the heat subsides, get a cool place to get a rest and drink plenty of water.

Before going for a surgery, make sure that you inform the doctor or dentist of all the medicated products you use.

As previously mentioned, children below the age of six should never be given Uribel since they are more sensitive and can develop more severe symptoms which begin with hyperactivity, hot and dehydrated skin, and producing less sweat than normal.

Salicylate, which is associated with aspirin, should not be given to children or even teenagers that have chickenpox, flu, any unknown illness or recent viral infection without getting a go ahead from the doctor. Reye’s syndrome, which is extremely rare can occur.

Older adults are not as resistant to developing symptoms as children are. They can develop anxiety, costiveness, straining when urinating, confusion, dizziness and unexplained restlessness.

Since this drug is harmful to unborn babies, it should not be given to expectant mothers.

It can also be passed onto breast milk and have unpleasant effects on breastfeeding children. Ask the doctor for recommendations before taking this drug or breastfeeding.

7 Additional and vital information about Uribel that you should be aware of

Some drugs are not compatible when taken with Uribel and you should not adopt or drop any drug taking patterns unless you have fully informed and consulted with your doctor.

When taking antidepressants or psychiatric medication, do not hesitate to inform the doctor if you develop symptoms such as excessive sweating, hyperactivity, loose bowels, uncontrolled coordination and muscle jerking.

If you skipped a dose take it as soon as you remember, but if it is closer to the next dose, do not overdose by taking the missed dose.

8 Which drugs affect the use of Uribel?

To be on the safe side, always tell your doctor if you are taking medication since there are very many drugs which can react with methylene blue. You can be advised to stop taking some medicines before you can be allowed to take Uribel. Nonetheless, do not start or stop taking any drugs unless the doctor told you to do so. If there may be symptoms associated with side effects, inform the doctor to find the best treatment plan.

Such medicines which the doctor should know about include:

  • Any class of antidepressants
  • Diet pills, stimulants, cold or antihistamines, ADHD medication
  • Narcotic pain medicine
  • Medication to treat Parkinson’s disease or any restless leg syndrome
  • A severe headache medication

Taking any of the above medicines alongside Uribel can initiate serotonin problems. Call your doctor immediately if you develop life-threatening symptoms such as severe headaches or hallucinations among other symptoms.

Many of the drugs taken can react with methylene blue. Since not all symptoms are known, inform your doctor if you begin to notice any unexplained symptoms that persist. Tell your doctor about all medicines you take particularly:

  • A diuretic water pill
  • Medicines that interfere with the acidity of urine
  • Medications for bladder or urinary complications such as oxybutynin and darifenacin
  • Any drug containing sulfur

There are also some over the counter drugs which react with methenamine and methylene blue. Such may include some vitamin supplements and herbal products. Give a detailed list of all medicinal products that you use to your doctor.

9 Substances to avoid when taking Uribel

Avoid taking anti-acids or stool hardeners before one hour elapses after taking Uribel. Anti-acid or anti diarrhea medications can make it harder for some ingredients contained in uribel to be absorbed, for example hyoscyamine.

Wait for at least two hours after taking ketoconazole (nizoral) before you can take Uribel.

10 Expectations after taking Uribel

  • Even if you are an adult taking 4 pills a day, follow the doctor’s orders when taking Uribel.
  • Younger adults should follow doctors’ recommended dosage. Uribel should not be given to children under the age of six.
  • Each capsule should be taken with plenty amounts of water.
  • Uribel may be used alongside other antibiotic therapies, but you should seek the doctor’s advice to know which ones are compatible with no possible harmful effects.
  • Do not overdose or abuse the drug.
  • Urine or stool may change color to blue, however, this is no cause for alarm and you should still take the drug as normal.

11 What makes Uribel effective?

Urinary tract discomfort can be solved effectively by taking Uribel. Doctors prescribe this medicine since it has effective ingredients, usually pain relievers. Uribel has five main ingredients including; antiseptic agents to act against the growth of bacteria in the urinary tract, antispasmodics which calm the muscles lining the urinary tract, and pain relievers which relieve you from the burning feel when urinating and the associated pain.

12 Where is the best place to store your medicine?

  • Keep them at a place where they cannot be accessed by children.
  • Keep them at a constant temperature, preferably room temperature.
  • Throw away any expired medicines and do not attempt to take them since they may be poisonous and very harmful to your health.

13 What is phosenamine?

Phosenamine is an antispasmodic, antiseptic and pain reliever drug, used to treat bladder irritation related to an infection or a medical procedure. It can be used to treat urinary issues such as symptoms of a urinary tract infections. This is a drug combination of hyoscyamine, methenamine, methylene blue and phenyl salicylate.

Hyoscyamine relieves spasms or cramps by relaxing the muscles of the urinary tract. Methenamine and methylene blue are the antiseptic components of Phosenamine.

These medications inhibit bacterial growth in the urine. Phenyl salicylate relieves the burning sensation and pain in the bladder and urinary tract.


Read your medication guide and follow your doctor’s prescription at all times.

  • Take Phosenamine orally or by mouth after meals or with food to prevent stomach upset, 4 times a day per doctor’s prescription.
  • Do not break, chew or crush enteric- coated tablet form of Phosenamine to prevent releasing the content of this medication all at once, which may intensify side effects.
  • The dosage depends on your medical condition, age, weight or treatment response. Do not adjust your dose without your doctor’s recommendation. Do not give this medicine to children less than 6 years old.
  • If you are prescribed to take antacids, take these drugs 1 hour after your Phosenamine dose.
  • Avoid intake of food or drinks that are high in tyramine content (i.e. aged cheese, aged/ dried meat, sausages, soy sauce, tofu, tap beer, etc.).
  • Avoid intake of caffeinated foods and drinks (i.e. coffee, tea, soft drinks, chocolate) to prevent serious side effects from this medication.
  • Avoid taking MAO inhibitor drugs 14 days before or after and during your Phosenamine treatment.
  • Avoid activities that require mental alertness (i.e. driving, operating machinery) because this medication can cause dizziness.
  • Avoid smoking and alcohol intake while on Phosenamine to prevent stomach bleeding.
  • Do not engage in activities that may cause your body to overheat such as heavy exercise during hot weather or using hot tubs as these may increase your risk of having heatstroke. Likewise, increase your fluid intake and wear light clothes.
  • Continue taking Phosenamine on a regular schedule (same time of the day). Do not stop taking this medication abruptly without consulting your doctor.

Inform your doctor immediately if your condition aggravates or does not improve.

Take your missed dose as soon as possible. However, make sure that the time interval between the missed and the next dose is not too close. Otherwise, stick with the regular schedule and leave out the missed dose. Do not double dose to cover up a missed dose. Record your missed dose and inform your doctor immediately if you missed several doses.


Phosenamine may interact with:

  • Bupropion
  • Buspirone
  • Carbamazepine
  • Methotrexate
  • Mifepristone
  • Potassium supplement
  • Pramlintide
  • Tetrabenzine
  • Certain narcotic medications (i.e. fentanyl, meperidine, methadone)
  • Anti- Parkinson’s medications (i.e. levodopa, tolcapone)
  • Medications for glaucoma (i.e. apraclonidine, brimonidine)
  • Antihypertensive or high blood pressure drugs (i.e. guanethididne, methyldopa)
  • Sulfamethoxazole
  • Antacids
  • Sodium bicarbonate
  • Potassium or sodium citrate
  • Acetazolamide
  • Hydrochlorothiazide
  • Antiplatelet drugs (i.e. clopidogrel)
  • Blood thinner medications (i.e. warfarin, enoxaparin)
  • MAO inhibitor medications (i.e. isocarboxazid, phenelzine, procarbazine, selegiline)
  • Dextromethorphan
  • Lithium
  • Sibutramine
  • Street drugs (i.e. ecstasy)
  • Tramadol
  • Tryptophan
  • Antidepressant medications (i.e. citalopram, paroxetine, venlafaxine)
  • Sumatriptan
  • Herbal products (i.e. ephedra)
  • Nasal decongestant drugs (i.e. phenylephrine, pseudoephedrine)
  • Stimulant drugs (i.e. amphetamine, ephedrine, epinephrine)
  • Diet aids
  • Azole antifungals (i.e. ketoconazole, itraconazole)
  • NSAIDs (i.e. ibuprofen, naproxen)
  • Antihistamine medicine (i.e. cetirizine, diphenhydramine)
  • Sleeping pills and anti-anxiety drugs (i.e. alprazolam, diazepam, zolpidem)
  • Muscle relaxant and
  • Narcotic pain reliever (i.e. codeine)

Some drugs may either lessen the beneficial effects or worsen the side effects of Phosenamine. Likewise, Phosenamine may make some drugs less efficient or intensify their side effects. Make sure to inform your doctor about all other drugs you are currently taking or using (prescribed and non-prescribed medications including vitamins, minerals, and herbal products) to check for possible drug interaction with Phosenamine.

Uribel, Urelle, Phosphasal and Ustell are similar drugs. 

Never alter the doses of other medications while on Phosenamine without your doctor’s recommendation.

Side Effects:

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking Phosenamine, tell your health care provider if you have/are:

  • Any allergies to any substance, food or medication, particularly to Phosenamine, hyoscyamine, methenamine, methylene blue and phenyl salicylate
  • Pregnant, planning to get pregnant or currently breastfeeding a baby.

It is not known if Phosenamine can harm the unborn child, but it can pass through breast milk that may harm the nursing child. The risks and benefits of using this medication during pregnancy must be discussed with your doctor.