1 What is Zinacef?

Brand: Zinacef

Generic: Cefuroxime

Zinacef is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.

This medicine is available only with your doctor's prescription. This product is available in the following dosage forms:

  • Powder for Solution
  • Solution
Have a question aboutZinacef Injection?Ask a doctor now

2 What to Know Before Using

Before using Zinacef, you must know all about the risks and complications associated with it. This is a decision you and your doctor will make.

For this medicine, the following should be considered:

Allergies: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric Population: This medicine has been tested in children and, in effective doses, has not shown to cause different side effects or problems than it does in adults.

Geriatric Population: This medicine has been tested in the elderly and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy: All Trimesters: Category C: Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding: Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions: Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose or other precautions may be necessary.

Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions: Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems: The presence of other medical problems may affect the use of this medicine.

Make sure you tell your doctor if you have any other medical problems, especially:

  • Colitis, history of 
  • Gastrointestinal disease, history of— cefuroxime may make these worse
  • Kidney disease 
  • Liver disease 
  • Poor nutritional status—these may be worsened by cefuroxime and you may need to have vitamin K
  • Kidney problems, temporary or permanent— these may affect how much cefuroxime is in your body, reducing your dose might be needed

3 Proper Usage

To use Zinacef properly, you must follow all instructions given by your doctor.

Dosing: The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For injection dosage form:

Adults and teenagers: 750 mg to 3 grams every six to eight hours usually for 5 to 14 days, injected into a muscle or vein. Gonorrhea is treated with a single dose of 1.5 grams, injected into a muscle; the total 1.5-gram dose is divided into two doses and injected into muscles at two separate places on the body, and given along with a single, oral 1-gram dose of probenecid.

Infants and children 1 month of age and older: 12.5 to 150 mg per kg (5.68 to 68 mg per pound) of body weight every six to eight hours, injected into a muscle or vein. Newborns—30 to 100 mg per kg (13.6 to 45.5 mg per pound) of body weight every eight to twelve hours, injected into a vein.

Infants and children 1 month of age and older: 12.5 to 150 mg per kg (5.68 to 68 mg per pound) of body weight every six to eight hours, injected into a muscle or vein.

Newborns: 30 to 100 mg per kg (13.6 to 45.5 mg per pound) of body weight every eight to twelve hours, injected into a vein.

Missed Dose: If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage: Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use. Consult your health care professional about how to store this medicine.

4 Precautions to Take

In using Zinacef, you must be careful and take some precautions as advised by your doctor. If your symptoms do not improve within a few days or if they become worse, check with your doctor.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Zinacef. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common:

Less common:

  • abdominal or stomach cramps
  • abdominal or stomach tenderness or pain
  • bloating
  • bluish color or changes in skin color
  • diarrhea, watery and severe, which may also be bloody
  • difficulty in breathing or swallowing, wheezing, shortness of breath
  • fast heartbeat
  • fever
  • hives or welts
  • increased thirst
  • muscle spasm or jerking of all extremities
  • nausea or vomiting
  • pain
  • skin itching, rash, or redness
  • sudden loss of consciousness
  • swelling of face, throat, or tongue
  • swelling of foot or leg
  • tenderness
  • unusual weight loss


  • blistering, peeling, loosening of the skin
  • bloody or cloudy urine
  • dizziness
  • fast heartbeat
  • greatly decreased the frequency of urination or amount of urine
  • hearing loss, mild to moderate
  • joint or muscle pain
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red or irritated eyes
  • redness, tenderness, itching, burning or peeling of skin
  • red skin lesions, often with a purple center
  • sore throat
  • tightness in the chest

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common:

  • gas
  • loss of appetite

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.