ZyPREXA IntraMuscular

1 What is ZyPREXA IntraMuscular?

Brand: ZyPREXA IntraMuscular, ZyPREXA Relprevv

Generic: Olanzapine

ZyPREXA IntraMuscular is an atypical antipsychotic drug used for the treatment of agitation that occurs with schizophrenia and bipolar mania.

This drug is contraindicated for use in the treatment behavioral problems in older adult patients who have dementia or Alzheimer's disease. This drug requires a prescription.

Zyprexa RelprevvВ® is available only through a special restricted distribution program called Zyprexa RelprevvВ® patient care program.

2 What to Know Before Using

Before using ZyPREXA IntraMuscular, you must know all about the risks and complications associated with it.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals. Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

Studies in children regarding the correlation of age to the effects of olanzapine injection have not been performed while safety and efficacy have not been established.

Studies in the elderly have not demonstrated any geriatric-specific problems that would limit the utility of olanzapine injection. Adjustments in the dose of the elderly may be required since they are more likely to have dementia or age-related liver, kidney, or heart problems.

Adverse effects have been reported in animal studies but studies in pregnant women or animals are still inadequate. Infant risk is still undetermined when using this drug during breastfeeding.

Discuss with your healthcare professional about the potential risks and benefits before of taking this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as:

  • Amifampridine
  • Bepridil
  • Cisapride
  • Dronedarone
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone
  • Amiodarone
  • Anagrelide
  • Aripiprazole
  • Arsenic Trioxide
  • Bromazepam
  • Buprenorphine
  • Buserelin
  • Carbamazepine
  • Clarithromycin
  • Clomipramine
  • Crizotinib
  • Dabrafenib
  • Degarelix
  • Delamanid
  • Deslorelin
  • Diazepam
  • Donepezil
  • Escitalopram
  • Fentanyl
  • Flibanserin
  • Fluoxetine
  • Gonadorelin
  • Goserelin
  • Histrelin
  • Hydrocodone
  • Hydromorphone
  • Hydroxychloroquine
  • Ivabradine
  • Ketoconazole
  • Leuprolide
  • Levofloxacin
  • Lithium
  • Lorazepam
  • Methadone
  • Metronidazole
  • Midazolam
  • Milnacipran
  • Mirtazapine
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Ondansetron
  • Oxycodone
  • Oxymorphone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pixantrone
  • Quetiapine
  • Sevoflurane
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Tetrabenazine
  • Tramadol
  • Triptorelin
  • Vandetanib
  • Vemurafenib
  • Vinflunine
  • Amprenavir
  • Betel Nut
  • Ciprofloxacin
  • Fluvoxamine
  • Fosamprenavir
  • Haloperidol
  • Ritonavir
  • Valproic Acid

Intake of specific food or using alcohol or tobacco with this drug is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare professional if you have any other medical problems such as:

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3 Proper Usage

Proper usage of ZyPREXA IntraMuscular requires strict adherence to your doctor’s orders. A trained healthcare professional will give you this drug in a clinic, community health center, or hospital. This drug is injected into one of your muscles.

You will be switched to an oral drug that works the same way when your condition improves. It is recommended to only use the brand of this drug that your doctor prescribed, as different brands may not work the same way.

Inform your healthcare professional if you smoke tobacco, as you might need a different amount of this drug if you smoke.

4 Precautions to Take

Before using ZyPREXA IntraMuscular, there are some precautions you must take. Regular visits should be made to your healthcare provider to track your progress and to monitor the effectiveness of the drug. Unwanted effects can be screened using blood tests.

This drug may cause agitation, irritability, or other abnormal behaviors such as suicidal thoughts and tendencies or to become more depressed. Inform your healthcare professional immediately if you notice any of these unwanted effects.

The cholesterol and fats levels in your blood may be increased by this drug. You will be given drugs that can lower the amount of cholesterol and fats in the blood if this happens.

Your healthcare professional will monitor your weight regularly during treatment with this drug, as weight changes have been reported with the use of this drug.

This drug may increase the amount of sugar in your blood. Check with your healthcare professional immediately if you have increased thirst or increased urination.

If you have diabetes, you may notice a change in the results of your urine or blood sugar tests.

Check with your healthcare professional immediately if you have any symptoms of neuroleptic malignant syndrome such as:

  • convulsions
  • the difficulty with breathing
  • a fast heartbeat
  • a high fever
  • high or low blood pressure
  • increased sweating
  • loss of bladder control
  • severe muscle stiffness
  • unusually pale skin
  • tiredness

Check with your healthcare professional immediately if you have any symptoms of tardive dyskinesia such as:

  • lip smacking or puckering
  • puffing of the cheeks
  • rapid or worm-like movements of the tongue
  • uncontrolled chewing movements
  • uncontrolled movements of the arms and legs

Olanzapine injection may cause drowsiness, trouble with thinking, trouble with controlling body movements, or trouble with your vision.

Be careful in taking this drug before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help.

This drug may cause post-injection delirium/sedation syndrome which can manifest as convulsions, dizziness, drowsiness, sleepiness, or confusion as to time, place, or person after receiving the injection.

This drug can temporarily cause leukopenia which can increase the chance of getting an infection. It is recommended to avoid people with infections.

Check with your healthcare professional immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. You might get overheated while using this drug.

It is recommended to increase fluid intake during hot weather while exercising, or while using a hot tub or sauna. You might feel dizzy, weak, tired, or confused when you are dehydrated.

You might have an upset stomach or vomit. Call your healthcare professional if drinking cool water and moving away from the heat does not cool you down.

Intake of alcohol is not recommended while you are receiving this drug. Consult with your healthcare professional before taking any other prescription or nonprescription drugs, and herbal or vitamin supplements.

5 Potential Side Effects

As with many medications, there are several potential side effects associated with ZyPREXA IntraMuscular. Side effects may vary for each individual and prompt medical attention should be given if they occur.

Seek advice from your healthcare professional immediately if you experience any unusual symptoms such as:

  • bloating or swelling of the face, arms, hands, lower legs or feet
  • blurred vision
  • change in vision
  • change in walking and balance
  • clumsiness or unsteadiness
  • the difficulty with speaking
  • the difficulty with swallowing
  • drooling
  • impaired vision
  • inability to sit still
  • loss of balance control
  • mask-like face
  • muscle trembling, jerking or stiffness, need to keep moving
  • rapid weight gain
  • restlessness
  • shakiness in the legs, arms, hands or feet
  • shuffling walk
  • slowed movements
  • slurred speech
  • the stiffness of the arms and legs
  • tic-like movements of the head, face, mouth, and neck
  • tingling of the hands or feet
  • trembling or shaking of the fingers, hands or feet
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unusual weight gains or loss
  • bladder pain
  • bloody or cloudy urine
  • bruising
  • burning
  • crawling
  • itching
  • numbness
  • prickling
  • "pins and needles" or tingling feelings
  • chest pain
  • difficult or labored breathing
  •  burning or painful urination
  • dizziness
  • excessive muscle tone
  • frequent urge to urinate
  • headache
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • itching of the vagina or genital area
  • lack of coordination
  • large, flat, blue or purplish patches in the skin
  • loss of bladder control
  • loss of memory
  • lower back or side pain
  • muscle tension or tightness
  • nervousness
  • pain
  • redness and swelling at the site of the injection
  • pounding in the ears
  • problems with memory
  • rhythmic movement of the muscles
  • shortness of breath
  • slow, fast, pounding or irregular heartbeat or pulse
  • speaking is less clear than usual
  • sticking out the tongue
  • thick, white vaginal discharge with no odor or with a mild odor
  • tightness in the chest
  • trouble with breathing, speaking or swallowing
  • twitching
  • uncontrolled twisting movements of the neck, trunk, arms or legs
  • unusual or incomplete body or facial movement
  • the weakness of the arms and legs
  • wheezing

Some side effects may occur that usually do not need medical attention. As your body adjusts to the medicine, the side effects will slowly disappear. Ask your healthcare professional about ways to prevent or reduce some of these side effects.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.

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