Antipsychotics can be used when SSRIs don't work
Sometimes, we also use antipsychotics for cases of depression when SSRIs are simply not working. For example, Seroquel (quetiapine) and Abilify are widely used for bipolar or psychosis and have been used in difficult-to-treat cases of depression too. It's especially helpful for those who have trouble sleeping because they have a slightly sedating effect as well. However, these may be dangerous for people who need to operate machinery regularly. Other side effects of these medications can actually be quite serious too, and can include weight gain, diabetes, and even sudden cardiac death. It's really important to have a thorough discussion with your doctor when considering anti-psychotics for depression.