Plantar warts, if that is, in fact, the correct diagnosis for what you are experiencing, are usually treated in different ways by different practitioners. Some physicians will treat the warts with topical treatments, such as acids or blistering agents. Some physicians will freeze the warts. Some physicians will laser the warts. Some physicians will even inject the warts with different kinds of medicines. True plantar warts (Verruca Plantaris) is caused by a viral infection. The virus lives in the deepest layer of the dermis (7th layer), and the virus must be eradicated or the lesions will not resolve. This may take several treatments, as verruca are very difficult to get rid of and have a high recurrence rate. This is because the virus needs to be killed. There are really no oral medications that are effective against warts.