1. Ask your doctor what regimen is being recommended
2. Ask your doctor what he/she expects
3. Consult the NCCN www.nccn.org guidelines. They have a patient guideline available that is an accurate source of information.
Recent advances in lung cancer mean that oncologists will typically run special tests to see if patients should get immunotherapy, new targeted agents, or more traditional "cytotoxic" chemotherapy.
Side effects from these various regimens vary significantly so it is hard to give a simple answer to this question. The severity of side effects also range from mild to occasional severe side effects.
I recommend a personalized discussion with the treating oncologist about the specific regimen being prescribed.