Endocrinology-Diabetes Questions Endocrinology-Diabetes

Is hyperthyroidism a genetic condition?

I am a 19 year old female. I want to know if hyperthyroidism a genetic condition?

6 Answers

The cause of hyperthyroidism is unknown at present. We do know it is much more common in women. Up till now, it is not considered a genetic disease.

A. Donald Angeletti, MD
Dear Patient,

About 2% of hyperthyroidism is due to genetics. Graves disease an autoimmune disease is most common cause of hyperthyroidism. It may also occur as part of Hashimotos, another autoimmune disorder. Other causes include excess iodine intake, use of meds such as Amiodarone, and, rarely, pituitary disorders.

Respectfully,

Marvin A. Leder, MD FACP FACE
The tendency to become hyperthyroid, either because of hyperactive nodules or because of autoimmune Graves’ disease, does run in families. So it is particularly genetic, but weakly so. For example, with autoimmune diseases, the tendency to get ANY autoimmune disease is inherited genetically, but WHICH autoimmune disease, if any, is mainly luck of the draw... which virus happens to set off your immune system at an unlucky time...
There is an increased incidence of hyperthyroidism in relatives of affected patients. It is not inherited by classical mendelian genetics and therefore cannot be considered a genetic condition.

Edward N, Smolar, MD
Hyperthyroidism is a big umbrella that covers a medical condition characterized for excessive production of thyroid hormone by the thyroid gland. The most common reason for hyperthyroidism is an autoimmune condition called Grave's disease. Autoimmune diseases may be genetic and express as different diseases in family members (Hashimoto's thyroiditis,
Type 1 diabetes mellitus, Alopecia, Psoriasis, Adrenal Insufficiency, Vitiligo, Rheumatoid Arthritis, Lupus, etc.). If you have hyperthyroidism it is important to determine what is the cause, an answer that must be given by your endocrinologist.
Some forms, like Graves’ disease can be genetic