“Tooth pain ”

One potential side effect of taking amoxicillin with methotrexate is an increased risk of methotrexate toxicity. Methotrexate is primarily cleared from the body by the kidneys, and amoxicillin can decrease kidney function, leading to higher levels of methotrexate in the body. This can increase the risk of side effects such as liver damage, gastrointestinal problems, and bone marrow suppression.
Other possible side effects of amoxicillin include allergic reactions, diarrhea, nausea, vomiting, and abdominal pain. If you experience any of these side effects or any other symptoms while taking amoxicillin with methotrexate, you should contact your doctor immediately.

There are some interactions between the two medications. Usage should be monitored by your physician. Contact your PCP/pharmacist for more specific information in regards to your regiment

These antibiotics interact with the way methotrexate is metabolized in the kidneys, potentially reducing the rate with which it is processed. This can lead to a buildup that can slowly cause toxicity.

I don't know. I am only a dentist. The best persons to speak to about this would be your physician who prescribed the methotrexate and/or a pharmacist.

There can be some interactions between the 2 meds. I would finish the antibiotic first before starting the methotrexate.

There is no listed drug interactions between Amoxicillin and Methotrexate according the the physicians desk reference.

Michael Neveu, DMD