“Will prozac use lead to weight gain?”

Overall, Prozac is generally considered to be a "weight-neutral" medication, meaning that a small proportion of patients lose weight, a small proportion gain weight (typically very little, but occasionally a significant amount), and most neither gain nor lose weight. If your treating provider believes Prozac would be a good medication choice, it would be worth trying. If it was going to cause you to gain weight, you would likely have a noticeable increase in appetite. In that case, the medication could be discontinued before any weight gain occurred. Another factor to consider with antidepressants and weight gain or loss is this: Most people with anxiety -- and some with depression -- endorse a decreased appetite. When their antidepressant causes remission of their mood symptoms, their appetite normalizes (increases), causing weight gain. This type of weight gain is often incorrectly blamed on the antidepressant.
As you can see, there is no simple answer to your question, but I'll try to sum it up: Prozac is unlikely to cause weight gain, but if your appetite spikes after starting Prozac, inform your physician so that they can change your antidepressant.
I hope that helps.

Sincerely,

Dr. Lisa Fairweather

It should not as prozac (or fluoxetine) is the only weight neutral (not likely to cause weight gain or weigh loss) SSRI, and one of three weight neutral antidepressants, with the two others being Venlafaxine and Buproprion. At times, people who feel better regain their appetite and gain a few pounds post initiation of treatment. This may be the reason. Either way, I recommend discussing with your physician.

It is dependent upon you as an individual. Generally, I do not expect significant weight gain on fluoxetine and there are others who may lose weight or have appetite suppression. This may partially depend on the dose you take.